314020-40-1

Basic information

• Product Name: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide
• Synonyms: 2-(2,6-Diethyl-4-methylphenyl)malonamide; propanediamide, 2-(2,6-diethyl-4-methylphenyl)-
• CAS NO: 314020-40-1
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.32
• Mol File: 314020-40-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 450.8°C at 760 mmHg
• Flash Point: 226.4°C
• Density: 1.113g/cm³
• Vapor Pressure: 2.57E-08mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide(314020-40-1)
• EPA Substance Registry System: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide(314020-40-1)

Safety Data

• Hazardous Substances Data: 314020-40-1(Hazardous Substances Data)

Usage

General Description

2-(2,6-diethyl-4-methyl-phenyl)propanediamide is a chemical compound with the molecular formula C16H26N2O. It is a white solid that is soluble in organic solvents and has a melting point of 157-159°C. 2-(2,6-diethyl-4-methyl-phenyl)propanediamide is commonly used as a pharmaceutical intermediate in the synthesis of various drugs, including analgesics and anti-inflammatory medications. It also has potential applications in the field of organic chemistry as a building block for the synthesis of more complex molecules. Additionally, 2-(2,6-diethyl-4-methyl-phenyl)propanediamide may have other industrial and commercial uses, although its exact properties and applications have not been extensively studied or documented.

Upstream product

• 314084-61-2 1-bromo-2,6-diethyl-4-methylbenzene 
• 314020-53-6 2-(2,6-diethyl-4-methylbenzene)malononitrile 
• 24544-08-9 2,6-diethyl-4-methylaniline 

Downstream Products

• 1416807-67-4 8-(2,6-diethyl-4-methylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione 
• 243973-20-8 pinoxaden 

Relevant articles and documents

Method for preparing 2-arylmalonic acid derivative, intermediate and application thereof

The invention provides a method for preparing a 2-arylmalonic acid derivative, an intermediate and application thereof. According to the method, a cyclohexadiene compound is used as a raw material, and the 2-arylmalonic acid derivative 3 is obtained through an isomerization reaction, a halogenation reaction in the presence of a halogenation reagent and a dehydrohalogenation aromatization reactionat a certain temperature in sequence. Compared with the prior art, the method has the following remarkable characteristics and advantages: (1) expensive metal catalysts are not needed in the reaction;(2) strong base with potential safety hazards is not needed in the reaction; and (3) the reaction is safe, the conditions are mild, the yield is high, the cost is low, and industrial production is facilitated.

Halogenated conjugated diene compound and preparation method and application thereof

The invention provides a novel halogenated conjugated diene compound 1 as well as a preparation method and application thereof. A conjugated diene compound is used as a raw material and is subjected to halogenation reaction to obtain a compound 1. A 2-aryl malonic acid derivative obtained by dehydrohalogenation aromatization reaction of the compound 1 can be applied to synthesis of a compound withbiological activity. The invention has the following remarkable characteristics and advantages: (1) the invention provides a novel halogenated conjugated diene compound 1 and a synthetic method thereof; and (2) the new compound 1 with the multifunctional group can be used for synthesizing other compounds with important values through further functional group conversion reaction.

Method for preparing 2,6-diethyl-4-methylphenylmalonamide

The invention relates to a method for preparing 2,6-diethyl-4-methylphenylmalonamide. The method comprises the following steps: catalyzing 2,6-diethyl-4-methylphenylmalonitrile and water in a polar solvent by transition metal oxides to carry out a hydrolysis reaction, thereby obtaining the 2,6-diethyl-4-methylphenylmalonamide, wherein a molar ratio of the 2,6-diethyl-4-methylphenylmalonitrile to the transition metal oxides is 1:(0.001-3.0); and the reaction temperature is 10-250 DEG C. The invention further relates to application of the 2,6-diethyl-4-methylphenylmalonamide in preparation of anherbicide pinoxaden intermediate. According to the preparation method of the 2,6-diethyl-4-methylphenylmalonamide, the 2,6-diethyl-4-methylphenylmalonitrile is subjected to catalytic hydrolysis by using the transition metal oxides, the preparation method is high in reaction speed, high in selectivity, mild in reaction condition and environmental-friendly, further hydrolysis of the product 2,6-diethyl-4-methylphenylmalonamide can be effectively avoided, and the method is suitable for industrial production.