314776-27-7

Basic information

• Product Name: 3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: 3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 314776-27-7
• Molecular Weight: 609.045
• Mol File: 314776-27-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate(314776-27-7)
• EPA Substance Registry System: 3-(2-cyanoethyl) 5-(3,3-diphenylpropyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate(314776-27-7)

Safety Data

• Hazardous Substances Data: 314776-27-7(Hazardous Substances Data)

Upstream product

• 314776-26-6 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 20017-67-8 3,3-diphenylpropan-1-ol 
• 193539-61-6 (Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester 
• 65193-87-5 2-cyanoethylacetoacetate 
• 314776-25-5 5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 874179-67-6 4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester 

Relevant articles and documents

Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels

Cilnidipine is a 1,4-dihydropyridine derived L/N-type calcium channel dual blocker possessing neuroprotective and analgesic effects which are related to its N-type calcium channel inhibitory activity. In order to find specific N-type calcium channel blockers with the least effects on cardiovascular system, we performed structure-activity relationship study on APJ2708, which is a derivative of cilnidipine, and found a promising N-type calcium channel blocker 21b possessing analgesic effect in vivo with a 1600-fold lower activity against L-type calcium channels than that of cilnidipine.