315-31-1

Basic information

• Product Name: 2-Fluoro-3-methylbenzoic acid
• Synonyms: Benzoic acid, 2-fluoro-3-methyl-;2-FLUORO-3-METHYLBENZOIC ACID;2-Fluoro-3-methylbenzoic acid 98%;2-Fluoro-3-methylbenzoicacid98%;2-Fluoro-m-toluic acid;2-Fluoro-m-toluic acid, 3-Carboxy-2-fluorotoluene
• CAS NO: 315-31-1
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.14
• Product Categories: Fluorin-contained Benzoic acid series;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid
• Mol File: 315-31-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 114-116
• Boiling Point: 258.351 °C at 760 mmHg
• Flash Point: 110.047 °C
• Appearance: /
• Density: 1.259 g/cm³
• Vapor Pressure: 0.544mmHg at 25°C
• Refractive Index: 1.472
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.34±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-3-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-3-methylbenzoic acid(315-31-1)
• EPA Substance Registry System: 2-Fluoro-3-methylbenzoic acid(315-31-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 315-31-1(Hazardous Substances Data)

Usage

Chemical Properties

off white powder

InChI:InChI=1/C4H3FN2/c5-4-6-2-1-3-7-4/h1-3H

Upstream product

• 95-52-3 2-Fluorotoluene 
• 124-38-9 carbon dioxide 

Downstream Products

• 307975-03-7 (2-fluoro-3-methylphenyl)methanol 
• 151412-12-3 2-fluoro-3-methylbenzyl bromide 
• 447463-07-2 (3-{4-[1-(2-fluoro-3-methyl-benzyloxy)-ethyl]-2-methoxy-5-nitro-phenoxy}-propyl)-carbamic acid tert-butyl ester 
• 586374-04-1 methyl 2-fluoro-3-methylbenzoate 
• 1124215-57-1 N-tert-butyl-2-fluoro-3-methylbenzamide 
• 171670-20-5 methyl 3-(bromomethyl)-2-fluorobenzoate 
• 1262419-96-4 methyl 2-fluoro-3-formylbenzoate 
• 680610-60-0 2-fluoro-N-methoxy-N,3-dimethylbenzamide 
• 865664-05-7 1-(2-fluoro-3-methylphenyl)ethan-1-one 

Relevant articles and documents

Meta -C-H arylation of fluoroarenes via traceless directing group relay strategy

While several methods for the ortho selective arylation of fluoroarenes, meta-functionalisation has never been achieved. We report a new methodology, based on the traceless directing group relay concept, leading to the first meta-selective (hetero)arylation of fluoroarenes. In this strategy, CO2 is introduced as a transient directing group, to control a Pd-catalysed arylation meta to the fluoro functionality, prior to its release in a sequential, one-pot fashion. This method has shown compatibility with a number of functional groups and substitution patterns in both the fluoroarene core and aryl iodide coupling partners, and proceeds with complete meta-selectivity and mono vs. bis-arylation selectivity.