31537-54-9

Basic information

• Product Name: Benzamide, N-(3-oxo-3-phenylpropyl)-
• CAS NO: 31537-54-9
• Molecular Formula: C16H15NO2
• Molecular Weight: 253.301
• Mol File: 31537-54-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(3-oxo-3-phenylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(3-oxo-3-phenylpropyl)-(31537-54-9)
• EPA Substance Registry System: Benzamide, N-(3-oxo-3-phenylpropyl)-(31537-54-9)

Safety Data

• Hazardous Substances Data: 31537-54-9(Hazardous Substances Data)

Upstream product

• 7646-66-4 N-benzoylaziridine 
• 120-12-7 anthracene 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 55-21-0 benzamide 
• 38792-42-6 N-(chloromethyl)benzamide 
• 6282-02-6 N-(hydroxymethyl)benzamide 
• 1256544-03-2 ethyl 2-(benzamidomethyl)-3-oxo-3-phenylpropanoate 
• 2677-69-2 3-amino-1-phenyl-propan-1-one 
• 98-88-4 benzoyl chloride 
• 43218-34-4 N-Benzoyl-β-alanine chloride 
• 71-43-2 benzene 

Downstream Products

• 80213-06-5 N-(3-hydroxy-3-phenylpropyl)benzamide 

Relevant articles and documents

Electron Attachment to N-Benzoylaziridines followed by C-N Homolysis of the Aziridine Ring

Reactions of N-benzoylaziridines with strong electron sources provide direct evidence for the formation of ketyls (2) and radicals (3), both of which are postulated intermediates in the single electron transfer mechanism of nucleophilic ring opening of activated aziridines.

Preparation method of beta-aminoketone

The invention discloses a preparation method of beta-aminoketone. According to the preparation method, aromatic ring substituted propargyl alcohol and amide are taken as raw materials, and tandem Meyer-Schuster rearrangement reaction and intermolecular amine hydrogenation addition reaction are performed by the action of acid, so that one-pot synthesis of beta-aminoketone is achieved. The maximum output of the preparation method of beta-aminoketone can reach 94%; the method has the advantages of simplicity in operation, 100% atom use ratio, economy and the like; and a novel synthesis method is provided for constructing beta-aminoketone compounds.

Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles

Inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD1) show promise as drugs to treat metabolic disease and CNS disorders such as cognitive impairment. A series of 1,5-substituted 1H-tetrazole 11β-HSD1 inhibitors has been discovered and chemically modified. Compounds are selective for 11β-HSD1 over 11β-HSD2 and possess good cellular potency in human and murine 11β-HSD1 assays. A range of in vitro stabilities are observed in human liver microsome assays.