3156-18-1

Basic information

• Product Name: 2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole
• Synonyms: 2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole;2-((4-chlorophenoxy)methyl)-1H-benzo[d]imidazole
• CAS NO: 3156-18-1
• Molecular Formula: C₁₄H₁₁ClN₂O
• Molecular Weight: 258.7
• Mol File: 3156-18-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 174 °C
• Boiling Point: 496.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.349±0.06 g/cm3(Predicted)
• PKA: 11.34±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole(3156-18-1)
• EPA Substance Registry System: 2-(4-Chloro-phenoxymethyl)-1H-benzoimidazole(3156-18-1)

Safety Data

• Hazardous Substances Data: 3156-18-1(Hazardous Substances Data)

Usage

Chemical structure

A benzimidazole derivative with a chlorine atom and a phenoxymethyl group attached to the benzene ring

Usage

Building block in the synthesis of various bioactive molecules in the pharmaceutical industry

Pharmacological activities

Antiviral, antifungal, anticancer, and anti-inflammatory properties

Specific properties and potential applications

Not widely studied, but may have potential as a drug candidate or as a precursor in organic synthesis due to its structural features.

Upstream product

• 122-88-3 4-Chlorophenoxyacetic acid 
• 95-54-5 1,2-diamino-benzene 
• 79397-26-5 N-(p-chlorophenoxyacetyl)phenylalanine methyl ester 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 
• 615-28-1 o-phenylenediamine dihydrochloride 
• 4857-04-9 2-chloromethyl-1H-benzimidazole 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 210564-62-8 4-{2-[2-(4-Chloro-phenoxymethyl)-benzoimidazol-1-yl]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 193626-31-2 4-{3-[2-(4-Chloro-phenoxymethyl)-benzoimidazol-1-yl]-propyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 210564-57-1 2-{2-[2-(4-Chloro-phenoxymethyl)-benzoimidazol-1-yl]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 750599-05-4 2-(4-chlorophenoxymethyl)-1H-benzimidazole acetic acid hydrazide 
• 1403579-55-4 C₁₇H₁₄ClN₄O₂S₂^(1-)*K⁽¹⁺⁾ 
• 1257231-31-4 4-amino-5-[2-(4-chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole 
• 1227751-28-1 C₂₄H₁₇ClN₆OS 
• 1227751-29-2 C₂₅H₁₉ClN₆OS 
• 1227751-30-5 C₂₅H₁₉ClN₆OS 
• 1227751-31-6 C₂₅H₁₉ClN₆OS 
• 1227751-32-7 C₂₅H₁₉ClN₆O₂S 
• 1227751-33-8 C₂₅H₁₉ClN₆O₂S 
• 1227751-34-9 C₂₅H₁₉ClN₆O₂S 
• 1227751-35-0 C₂₄H₁₆Cl₂N₆OS 

Relevant articles and documents

1-ethyl gallate-2-substituted phenoxymethyl benzimidazoles: Synthesis, molecular structure, antimicrobial activities and complex with Cr(III)

Summary: The design of gallate and benzimidazole containing derivatives is expected to produce new bioactive molecules with multiple applications. Here the synthesis of eight novel benzimidazole compounds containing ethyl gallate and substituted phenoxyme

BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT

The present invention is directed to a compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persistent sodium current, such as an ocular disorder, multiple sclerosis, seizure disorder, and chronic pain.

Synthesis and bioactivity of a novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles

A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4- thiadiazoles were synthesized by the condensation of 4-amino-5-[2-(4- chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole with various (un)substituted aromatic acids in the presence of phosphorous oxychloride. These compounds were investigated for their inhibitory activity to E. coli methionine aminopeptidase (EcMetAP1). Some of the tested compounds showed significant inhibitory activity.