31575-93-6

Basic information

• Product Name: heraclenol
• Synonyms: Helaclenin oxide;Heraclenin oxide;Komalin;Prangenin hydrate;Heraclel
• CAS NO: 31575-93-6
• Molecular Formula: C₁₆H₁₆O₆
• Molecular Weight: 304.296
• EINECS: 200-258-5
• Product Categories: Miscellaneous Natural Products
• Mol File: 31575-93-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 129-130 °C
• Boiling Point: 544.3°Cat760mmHg
• Flash Point: 283°C
• Appearance: /
• Density: 1.386g/cm³
• Vapor Pressure: 1.12E-12mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: 2-8°C
• PKA: 13.75±0.20(Predicted)
• CAS DataBase Reference: heraclenol(CAS DataBase Reference)
• NIST Chemistry Reference: heraclenol(31575-93-6)
• EPA Substance Registry System: heraclenol(31575-93-6)

Safety Data

• Hazardous Substances Data: 31575-93-6(Hazardous Substances Data)

Usage

General Description

Heraclenol is a chemical compound derived from the fruit peel of Heracleum persicum, also known as the Persian hogweed. It is a natural product that belongs to the class of coumarins, which are widely distributed in plants and have diverse biological activities. Heraclenol has been found to have potential anti-inflammatory, antioxidant, and antimicrobial properties. It has also been studied for its potential use in the treatment of various conditions, including cancer, cardiovascular diseases, and diabetes. Additionally, heraclenol has shown promise in the field of cosmetic and pharmaceutical industries due to its skin-protective and anti-aging effects. These findings suggest that heraclenol is a versatile compound with potential therapeutic applications in various fields.

InChI:InChI=1/C16H16O6/c1-16(2,19)11(17)8-21-15-13-10(5-6-20-13)7-9-3-4-12(18)22-14(9)15/h3-7,11,17,19H,8H2,1-2H3

Upstream product

• 35740-18-2 Prangenin 
• 482-44-0 imperatorin 
• 765316-44-7 (12R)-13-O-[β-D-apiofuranosyl-(1->6)-β-D-glucopyranosyl]heraclenol 

Relevant articles and documents

Biotransformation of imperatorin by Penicillium janthinellum. Anti-osteoporosis activities of its metabolites

Imperatorin (IMP) is a major constituent of many herbal medicines and possesses anti-osteoporosis activity. The present research work aimed to study the biotransformation processes of IMP and evaluated the anti-osteoporosis activity of the transformed metabolites. Among 18 strains of filamentous fungi screened, Penicillium janthinellum AS 3.510 exhibited good capability to metabolise IMP to the new derivatives. Ten transformed products were isolated and purified, and their structures were identified accurately based on spectroscopic data. Eight metabolites (2-8 and 10) were novel and previously unreported. The major biotransformation reactions involved hydroxylation of the prenyloxy side-chain and the lactone ring-opening reaction of furocoumarin skeleton. In addition, anti-osteoporosis activities of all products (1-10) were evaluated using MC3T3-E1 cells. The results showed that products 5 and 8 had the best bioactivities in increasing MC3T3-E1 cell growth. These products could be used in future therapeutic regimens for treating osteoporosis.

CHROMONES AND COUMARINS FROM SKIMMIA LAUREOLA

The isolation and characterisation of chromones and coumarins, including the new chromone, skimminin, from S. laureola is reported. - Key Word Index: Skimmia laureola; Rutaceae; chromones; skimminin; coumarins; linear furanocoumarins.