3158-98-3

Basic information

• Product Name: 2-amino-5-chloro-alpha-methylbenzhydryl alcohol
• Synonyms: 2-amino-5-chloro-alpha-methylbenzhydryl alcohol;2-Amino-5-chloro-α-methyl-α-phenylbenzenemethanol;1-(5-Chloro-2-aMinophenyl)-1-phenylethanol;1-(2-AMino-5-chlorophenyl)-1-phenylethanol;2-AMino-5-chloro-α-Methyl-benzhydrol;BenzeneMethanol, 2-aMino-5-chloro-α-Methyl-α-phenyl-
• CAS NO: 3158-98-3
• Molecular Formula: C₁₄H₁₄ClNO
• Molecular Weight: 247.72006
• EINECS: 221-603-7
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 3158-98-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 93-94 °C
• Boiling Point: 412°Cat760mmHg
• Flash Point: 202.9°C
• Appearance: /
• Density: 1.251g/cm³
• Vapor Pressure: 1.59E-07mmHg at 25°C
• Refractive Index: 1.63
• Solubility: Chloroform, Dichloromethane, Diethyl Ether
• PKA: 13.19±0.29(Predicted)
• CAS DataBase Reference: 2-amino-5-chloro-alpha-methylbenzhydryl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-chloro-alpha-methylbenzhydryl alcohol(3158-98-3)
• EPA Substance Registry System: 2-amino-5-chloro-alpha-methylbenzhydryl alcohol(3158-98-3)

Safety Data

• Hazardous Substances Data: 3158-98-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

InChI:InChI=1/C14H14ClNO/c1-14(17,10-5-3-2-4-6-10)12-9-11(15)7-8-13(12)16/h2-9,17H,16H2,1H3

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 74-88-4 methyl iodide 
• 75-16-1 methylmagnesium bromide 
• 1685-19-4 2-amino-5-chloroacetophenone 
• 100-58-3 phenylmagnesium bromide 
• 917-64-6 methyl magnesium iodide 

Downstream Products

• 68054-98-8 C₁₇H₁₆Cl₂N₂O₂ 
• 68055-00-5 C₂₀H₂₂Cl₂N₂O₃ 
• 68054-99-9 C₂₂H₁₈Cl₂N₂O₂ 
• 68182-92-3 C₂₁H₁₈Cl₂N₂O₃S 
• 68055-01-6 C₂₁H₁₇Cl₂N₃O₃ 
• 3158-99-4 1-phenyl-1-(2-amino-5-chlorophenyl)ethylene 
• 858621-43-9 7-acetyl-3-chloro-8-iodomethyl-8-phenylbicyclo[4.2.0]-7-azaocta-1,3,5-triene 
• 3159-00-0 N-[4-chloro-2-(1-phenylethenyl)phenyl]acetamide 
• 3159-01-1 4-chloro-2-(1-phenylethyl)benzenamine 
• 30169-33-6 6-Chlor-1,2-dihydro-4-phenylchinolin-2-on 

Relevant articles and documents

DEUTERATED ANALOGS OF ETIFOXINE, THEIR DERIVATIVES AND USES THEROF

This invention relates to deuterated analogs of etifoxine of Formula 1, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to methods for their preparation and use, and to pharmaceutical compositions. Briefly, this invention is generally directed to deuterated analogs of etifoxine as well as to methods for their preparation and use, and to pharmaceutical compositions containing the same.

Synthesis of benzazetine derivatives by intramolecular iodoamination of o-(acylamino)styrene derivatives

The iodoamination of o-(acylamino)styrene derivatives using iodine and sodium hydrogencarbonate, producing 7-acyl-8-iodomethylbicyclo[4.2.0]-7-azaoct- 1,3,5-triene [1-acyl-2-(iodomethyl)benzazetine] derivatives, is described. Replacement of the iodo moiety by hydrogen or phenylthio group is also reported.