31595-32-1Relevant articles and documents
Site-Selective Pd-Catalyzed C(sp3)?H Arylation of Heteroaromatic Ketones
Kudashev, Anton,Baudoin, Olivier
supporting information, p. 17688 - 17694 (2021/11/16)
A ligand-controlled site-selective C(sp3)?H arylation of heteroaromatic ketones has been developed using Pd catalysis. The reaction occurred selectively at the α- or β-position of the ketone side-chain. The switch from α- to β-arylation was realized by addition of a pyridone ligand. The α-arylation process showed broad scope and high site- and chemoselectivity, whereas the β-arylation was more limited. Mechanistic investigations suggested that α-arylation occurs through C?H activation/oxidative addition/reductive elimination whereas β-arylation involves desaturation and aryl insertion.
Enantioselective hydrogenation and transfer hydrogenation of bulky ketones catalysed by a ruthenium complex of a chiral tridentate ligand
Diaz-Valenzuela, M. Belen,Phillips, Scott D.,France, Marcia B.,Gunn, Mary E.,Clarke, Matthew L.
supporting information; experimental part, p. 1227 - 1232 (2009/08/10)
A study on the enantioselective hydrogenation of tertiary alkyl ketones catalysed by a novel class of tridentate-Ru complex is reported. In contrast to the extensively studied [RuCl2(diphos)(di-primary amine)] complexes, this new class of hydro
Enantioselective Allylic Substitutions Catalyzed by [(Hydroxyalkyl)pyridinooxazoline]- and [(Alkoxyalkyl)pyridinooxazoline]palladium Complexes
Nordstroem, Kerstin,Macedo, Emmanuel,Moberg, Christina
, p. 1604 - 1609 (2007/10/03)
Highly enantioselective (up to >99% ee) palladium-catalyzed substitution of rac-3-diphenyl-2-propenyl acetate with dimethyl malonate as nucleophile was achieved using 2-(1-hydroxyalkyl)-6-(4,5-dihydro-2-oxazolyl)pyridines and 2-(1-alkoxyalkyl)-6-(4,5-dihydro-2-oxazolyl)pyridines as ligands for palladium. The selectivity was found to be highly dependent on the nature of the substituants on the ligand and on the relative configuration of the two stereogenic centers present in the ligand. The results are discussed in terms of the conformation of the ligands in the intermediate π-allylpalladium complexes.