316-81-4 Usage
Description
Thioproperazine, also known as Thioridazine, is a phenothiazine derivative with a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10. It is a pharmaceutical compound that belongs to the class of neuroleptic agents and exhibits antipsychotic and tranquilizing properties.
Uses
Used in Pharmaceutical Industry:
Thioproperazine is used as an antipsychotic medication for the treatment of various psychiatric disorders, including schizophrenia, bipolar disorder, and severe depression. It works by blocking dopamine receptors in the brain, which helps to alleviate symptoms such as hallucinations, delusions, and agitation.
Additionally, Thioproperazine is used as a tranquilizer to manage anxiety and agitation in patients with various mental health conditions. Its calming effects can help to reduce tension and promote relaxation, making it a useful adjunct in the management of stress and anxiety disorders.
Originator
Majeptil,Specia,France,1960
Manufacturing Process
A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100
cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1-
piperazinyl)-1-chloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is
added and the mixture heated under reflux for 5 hours. After treatment of the
reaction products, a crude oily base (2.5 g) is obtained after treatment. By
the addition of a solution of fumaric acid in ethanol to an ethanolic solution of
the base, 3-dimethylsulfamoyl-10-(3-41-methyl-11-piperazinylpropyl)-
phenthiazinediacid fumarate (2.6 g) is obtained, melting point 182°C. The
base recrystallized from ethyl acetate melts at about 140°C.
Therapeutic Function
Neuroleptic, Antiemetic
Check Digit Verification of cas no
The CAS Registry Mumber 316-81-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 316-81:
(5*3)+(4*1)+(3*6)+(2*8)+(1*1)=54
54 % 10 = 4
So 316-81-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H30N4O2S2/c1-23(2)30(27,28)18-9-10-22-20(17-18)26(19-7-4-5-8-21(19)29-22)12-6-11-25-15-13-24(3)14-16-25/h4-5,7-10,17H,6,11-16H2,1-3H3