3161-21-5

Basic information

• Product Name: 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydroisoquinoline
• CAS NO: 3161-21-5
• Molecular Formula: C₂₀H₂₃NO₅
• Molecular Weight: 357.4003
• Mol File: 3161-21-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 484.3°C at 760 mmHg
• Flash Point: 197.7°C
• Density: 1.18g/cm³
• Vapor Pressure: 4.58E-09mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydroisoquinoline(3161-21-5)
• EPA Substance Registry System: 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydroisoquinoline(3161-21-5)

Safety Data

• Hazardous Substances Data: 3161-21-5(Hazardous Substances Data)

Upstream product

• 102240-27-7 N-(3',4'-dimethoxyphenethyl)-3,4,5-trimethoxybenzamide 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 24456-60-8 6,7-dimethoxy-1-(methylsulfanyl)-3,4-dihydroisoquinoline 
• 182163-96-8 3,4,5-trimethoxyphenylboronic Acid 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 33033-84-0 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 3161-13-5 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)isoquinoline 
• 32886-69-4 (S)-1-(3',4',5'-trimethoxylphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline 
• 33033-84-0 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 32886-70-7 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Josiphos-Type Binaphane Ligands for Iridium-Catalyzed Enantioselective Hydrogenation of 1-Aryl-Substituted Dihydroisoquinolines

Convenient synthesis and useful application of a series of Josiphos-type binaphane ligands were described. The iridium complexes of these chiral diphosphines displayed excellent enantioselectivity and good reactivity in the asymmetric hydrogenation of challenging 1-aryl-substituted dihydroisoquinoline substrates (full conversions, up to >99% ee, 4000 TON). The use of 40% HBr (aqueous solution) as an additive dramatically improved the asymmetric induction of these catalysts. This transformation provided a highly efficient and enantioselective access to chiral 1-aryl-substituted tetrahydroisoquinolines, which were of great importance and common in natural products and biologically active molecules.

Total synthesis of racemic 1-aryl-tetrahydroisoquinoline alkaloids

A new synthetic route was developed for the preparation of natural products cryptostyline I, II, III and 1-phenyl-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline. The Liebeskind-Srogl palladium-catalyzed carbon-carbon cross-coupling protocol was use