3161-52-2

Basic information

• Product Name: 3-Chloropropyl-N-benzylmethylamine
• Synonyms: 3-Chloropropyl-N-benzylmethylamine;N-Benzyl-3-chloro-N-methylpropylamine
• CAS NO: 3161-52-2
• Molecular Formula: C₁₁H₁₆ClN
• Molecular Weight: 197.70444
• Mol File: 3161-52-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 256.5°Cat760mmHg
• Flash Point: 108.9°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.0153mmHg at 25°C
• Refractive Index: 1.524
• PKA: 8.29±0.50(Predicted)
• CAS DataBase Reference: 3-Chloropropyl-N-benzylmethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloropropyl-N-benzylmethylamine(3161-52-2)
• EPA Substance Registry System: 3-Chloropropyl-N-benzylmethylamine(3161-52-2)

Safety Data

• Hazardous Substances Data: 3161-52-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H16ClN/c1-13(9-5-8-12)10-11-6-3-2-4-7-11/h2-4,6-7H,5,8-10H2,1H3

Upstream product

• 5814-42-6 3-(N-benzyl-N-methylamino)-propan-1-ol 
• 109-70-6 1.3-chlorobromopropane 
• 103-67-3 benzyl-methyl-amine 

Downstream Products

• 802033-93-8 5-[3-(benzyl-methyl-amino)-propyl]-10,11-dihydro-5H-benzo[b]thieno[2,3-f]azocin-4-one 
• 3318-16-9 benzyl-[3-(8-chloro-11H-dibenzo[b,f][1,4]thiazepin-10-yl)-propyl]-methyl-amine 
• 81087-63-0 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-[3-(N-benzyl-N-methylamino)propyl]-2,4(1H, 3H)-quinazolinedione 
• 98901-99-6 N¹-(phenylmethyl)-N¹-methyl-N²-(2-methyl-1-propyl)propane-1,3-diamine 
• 60630-68-4 N¹,N²-dimethyl-N¹-(phenylmethyl)-1,3-propanediamine 
• 98902-04-6 Tetrahydro-furan-2-carboxylic acid [3-(benzyl-methyl-amino)-propyl]-methyl-amide 
• 65189-24-4 N¹,N²-dimethyl-N²-(phenylmethyl)-N¹-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine 
• 94329-43-8 4-(N-benzyl-N-methylamino)butyraldehyde diethyl acetal 
• 220397-25-1 N-(toluene-4-sulfonyl)-L-prolyl-4-[3-(N-methyl-N-benzylamino)propoxy]-L-phenylalanine methyl ester 
• 165741-69-5 3-[3-(N-benzyl-N-methylamino)-propyloxy]-2-methyl-5-(2-fluorophenyl)-pyrazole 

Relevant articles and documents

Manganese-Catalyzed Anti-Markovnikov Hydroamination of Allyl Alcohols via Hydrogen-Borrowing Catalysis

Controlling the selectivity in a hydroamination reaction is an extremely challenging yet highly desirable task for the diversification of amines. In this article, a selective formal anti-Markovnikov hydroamination of allyl alcohols is presented. It enables the versatile synthesis of valuable γ-amino alcohol building blocks. A phosphine-free Earth's abundant manganese(I) complex catalyzed the reaction under hydrogen-borrowing conditions. A vast range of aliphatic, aromatic amines, drug molecules, and natural product derivatives underwent successful hydroamination with primary and secondary allylic alcohols with excellent functional group tolerance (57 examples). The catalysis could be performed on a gram scale and has been applied for the synthesis of drug molecules. The mechanistic studies revealed the metal-ligand bifunctionality as well as hemilability of the ligand backbone as the key design principle for the success of this catalysis.

Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands

The σ1 proteins are considered to be a new class of target structures for several central nervous system disorders, including depression, anxiety, psychosis, and Parkinson's and Alzheimer's diseases. Recently, the involvement of these receptors

Protected aminofunctionalized polymerization initiators and methods of making and using same

Anionic polymerization initiators useful in the preparation of polymers having a protected amine functional group. The amine functionality includes a first protecting group, which can be aralkyl, methyl, allyl or tertiary alkyl group. The other of the ami