316131-01-8 Usage
General Description
3,3-Difluoropyrrolidine is a chemical compound classified as an organofluorine and a halopyrrolidine. This means its structure contains a pyrrolidine ring, a five-membered ring with nitrogen as one of the atoms, with two fluorine atoms attached. It is mainly used in scientific research as a building block for larger organic compounds. The presence of the fluorine atoms in this compound makes it valuable in the field of medicinal chemistry because it can increase the biological activity and metabolic stability of the resulting compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 316131-01-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,6,1,3 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 316131-01:
(8*3)+(7*1)+(6*6)+(5*1)+(4*3)+(3*1)+(2*0)+(1*1)=88
88 % 10 = 8
So 316131-01-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H7F2N/c5-4(6)1-2-7-3-4/h7H,1-3H2
316131-01-8Relevant articles and documents
Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors
Caldwell, Charles G.,Chen, Ping,He, Jiafang,Parmee, Emma R.,Leiting, Barbara,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Eiermann, George J.,Petrov, Aleksandr,He, Huaibing,Lyons, Kathryn A.,Thornberry, Nancy A.,Weber, Ann E.
, p. 1265 - 1268 (2007/10/03)
Amides derived from fluorinated pyrrolidines and 4-substituted cyclohexylglycine analogues have been prepared and evaluated as inhibitors of dipeptidyl dipeptidase IV (DP-IV). Analogues which incorporated (S)-3-fluoropyrrolidine showed good selectivity for DP-IV over quiescent cell proline dipeptidase (QPP). Compound 48 had good pharmacokinetic properties and was orally active in an oral glucose tolerance test in lean mice.