316181-82-5

Basic information

• Product Name: 3-Acetyl-6-bromoindole
• Synonyms: 3-Acetyl-6-bromoindole;1-(6-BROMO-1H-INDOL-3-YL)ETHANONE;1-(6-broMo-1H-indol-3-yl)ethan-1-one
• CAS NO: 316181-82-5
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.08062
• Product Categories: Indole
• Mol File: 316181-82-5.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 388.995 °C at 760 mmHg
• Flash Point: 189.058 °C
• Appearance: /
• Density: 1.592 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.676
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Acetyl-6-bromoindole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Acetyl-6-bromoindole(316181-82-5)
• EPA Substance Registry System: 3-Acetyl-6-bromoindole(316181-82-5)

Safety Data

• Hazardous Substances Data: 316181-82-5(Hazardous Substances Data)

Usage

General Description

3-Acetyl-6-bromoindole is a chemical compound with the molecular formula C10H8BrNO. It is an indole derivative that contains both an acetyl and a bromine functional group. 3-Acetyl-6-bromoindole is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has potential applications in the field of medicinal chemistry, where it can be utilized in the development of new drugs and therapeutic agents. Additionally, 3-Acetyl-6-bromoindole is also used as a building block in the production of various organic molecules, making it a valuable chemical in the field of organic synthesis.

InChI:InChI=1/C10H8BrNO/c1-6(13)9-5-12-10-4-7(11)2-3-8(9)10/h2-5,12H,1H3

Upstream product

• 52415-29-9 6-bromo-1H-indole 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 224434-85-9 1-(6-bromo-1-tosyl-1H-indol-3-yl)ethan-1-one 
• 341998-58-1 (E)-1-(6-bromo-1-tosyl-1H-indol-3-yl)-3-(dimethylamino)prop-2-en-1-one 
• 290333-09-4 1-[1-[(4-methylphenyl)sulfonyl]-6-bromo-1H-indol-3-yl]-3-(dimethylamino)-2-propen-1-one 
• 1311395-23-9 4-(6-bromo-1H-indol-3-yl)-5-(4-acetylphenyl)pyrimidin-2-amine 
• 1311395-27-3 4-[2-amino-4-(6-bromo-1H-indol-3-yl)pyrimidin-5-yl]benzamide 
• 1311395-31-9 4-(6-bromo-1H-indol-3-yl)-5-(4-trifluoromethylphenyl)pyrimidin-2-amine 
• 1311395-35-3 4-(6-bromo-1H-indol-3-yl)-5-(3-methoxyphenyl)pyrimidin-2-amine 
• 289503-27-1 2-amino-4-(N-tosyl-6'-bromo-3'-indolyl)pyrimidine 

Relevant articles and documents

REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS

The present disclosure provides compounds of Formula IA and Formula IB and their pharmaceutical compositions as selective agonists of REV-ERB-α: where R1, R2, R3, R4, R5, RX1, RX2, nA, nB, X, Y, and Z are described herein. The compounds are useful in various methods and uses, such as in the treatment of diseases including hyperglycemia, dyslipidemia, atherosclerosis, and autoimmune and inflammatory disorders or diseases, and as cancer therapeutics, such as for the treatment of glioblastoma, hepatocellular carcinoma, and colorectal cancer, and for immune-oncology purposes.

Cascade Reaction to Selectively Synthesize Multifunctional Indole Derivatives by IrIII-Catalyzed C?H Activation

An effective and condition-controlled way to synthesize with high selectivity a variety of functionalized indoles with potent biological properties has been developed. Notably, 2,4-dialkynyl indole products were obtained by direct double C?H bond alkynylation, whereas alkynyl at the C4 position could convert to carbonyl to generate 2-alkynyl-3,4-diacetyl indoles fast and effectively. Additionally, a one-pot relay catalytic reaction led to 2,5-di-alkynyl-3,4-diacetyl indoles when using a carbonyl group as the directing group and by controlling the type and quantity of additives. A possible mechanism was proposed based on many studies including deuterium-exchange experiments, the necessary conditions of product conversion, and the effect of water on the reaction.

Preparation and application of pyrimidinedionoindole and pyridinonoindole compounds

The invention relates to a preparation method of a compound containing a pyrimidine-2, 4-diono[5, 4-b]indole skeleton or a pyridine-2-ono[3, 2-d]indole skeleton, and further relates to medical application of the compound serving as a BET Bromo structural domain inhibitor.