316373-95-2

Basic information

• Product Name: N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-methanesulfonyloxy-2-methyl-propionamide
• Synonyms: N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-methanesulfonyloxy-2-methyl-propionamide
• CAS NO: 316373-95-2
• Molecular Weight: 366.318
• Mol File: 316373-95-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-methanesulfonyloxy-2-methyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-methanesulfonyloxy-2-methyl-propionamide(316373-95-2)
• EPA Substance Registry System: N-[4-cyano-3-trifluoromethyl-phenyl]-2-hydroxy-3-methanesulfonyloxy-2-methyl-propionamide(316373-95-2)

Safety Data

• Hazardous Substances Data: 316373-95-2(Hazardous Substances Data)

Upstream product

• 90357-53-2 N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide 
• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 512776-91-9 N-[4-cyano-3-(trifluoromethyl)phenyl]-2,2,4-trimethyl-1,3-dioxolane-4-carboxamide 
• 316373-92-9 N-[4-cyano-3-(trifluoromethyl)-phenyl]-2,3-dihydroxy-2-methyl-propionamide 
• 124-63-0 methanesulfonyl chloride 
• 316373-94-1 (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2,3-dihydroxy-2-methylpropanamide 

Downstream Products

• 216665-25-7 N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-3-iodo-2-methylpropanamide 
• 216665-20-2 3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide 
• 90357-06-5 Bicalutamide 
• 90356-78-8 N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide 

Relevant articles and documents

Process for making bicalutamide and intermediates thereof

Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.

PROCESS FOR THE SYNTHESIS OF N-(4-CYANO-3-TRIFLUOROMETHYLPHENYL)-3-(4-FLUOROPHENYLSULPHONYL)-2-HYDROXY-2-METHYLPROPIONAMIDE

A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis.