3164-12-3

Basic information

• Product Name: 2-(3,4-Dichlorophenyl)benzoxazole
• Synonyms: 2-(3,4-Dichlorophenyl)benzoxazole
• CAS NO: 3164-12-3
• Molecular Formula: C₁₃H₇Cl₂NO
• Molecular Weight: 264.11
• Mol File: 3164-12-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 359.9°C at 760 mmHg
• Flash Point: 171.5°C
• Appearance: /
• Density: 1.399g/cm³
• Vapor Pressure: 4.76E-05mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 2-(3,4-Dichlorophenyl)benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-Dichlorophenyl)benzoxazole(3164-12-3)
• EPA Substance Registry System: 2-(3,4-Dichlorophenyl)benzoxazole(3164-12-3)

Safety Data

• Hazardous Substances Data: 3164-12-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H7Cl2NO/c14-9-6-5-8(7-10(9)15)13-16-11-3-1-2-4-12(11)17-13/h1-7H

Upstream product

• 95-55-6 2-amino-phenol 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 615-43-0 2-iodophenylamine 
• 3024-72-4 3,4-dichlorobenzoyl chloride 
• 615-36-1 2-bromoaniline 
• 51-44-5 3,4-dichlorbenzoic acid 
• 389840-44-2 C₁₃H₉Cl₂NO 

Relevant articles and documents

Oxidative NHC Catalysis for the Generation of Imidoyl Azoliums: Synthesis of Benzoxazoles

N-Heterocyclic carbene (NHC)-catalyzed intramolecular cyclization of aldimines generated from 2-amino phenols and aromatic aldehydes leading to the synthesis of 2-arylbenzoxazoles under mild conditions is presented. The reaction proceeds via the generation of the aza-Breslow intermediates from imines and NHC, which under oxidative conditions form the key imidoyl azoliums and a subsequent intramolecular cyclization furnishes the product. The reaction tolerates a broad range of functional groups, and the products are formed in generally good yields.

Trichloroisocyanuric Acid/Triphenylphosphine-Mediated Synthesis of Benzimidazoles, Benzoxazoles, and Benzothiazoles

A new and efficient method for preparation of benzimidazoles, benzoxazoles, and benzothiazoles from reactions of different carboxylic acids with o-phenylenediamine, o-aminophenol, and o-aminothiophenol in the presence of triphenylphosphine/trichloroisocyanuric acid system is presented. The desired products have been characterised on the basis of spectral (infrared, NMR, mass spectrometry) data, and the mechanism of their formation is proposed. The remarkable advantages are the inexpensive and readily available reagent, simple procedure, mild conditions, and good-to-excellent yields.

One-pot synthesis of 2-substituted benzoxazoles promoted by copper acetate monohydrate

An efficient synthesis of 2-substituted benzoxazoles via copper acetate monohydrate oxidative coupling of aldehydes with o-aminophenol is described. This synthetic strategy has some advantages as simple procedure, inexpensive and easily available catalyst, and facile isolation of the products in moderate to good yields.