31673-44-6Relevant articles and documents
Synthesis based on cyclohexadienes. Part 23. Total synthesis of 5-epi-pupukean-2-one
Kaliappan, Krishna,Subba Rao
, p. 3387 - 3392 (1997)
A new strategy for the construction of the isotwistane skeleton is reported from easily available cyclohexadienes which involves stereoselective alkylation of a bicyclooctenone derivative and a decarboxylative 5-exo-trig radical cyclisation as the key ste
Enantioselective enolate protonation with chiral anilines: Scope, structural requirements, and mechanistic implications
Vedejs,Kruger,Lee,Sakata,Stec,Suna
, p. 4602 - 4607 (2007/10/03)
High enantioselectivity has been demonstrated in the protonation of N,N- diisopropyl amides (Table, 1, entries 1-4, 7, and 10-13) derived from certain β,γ unsaturated acids. Depending on double bond geometry and the degree of substitution at the γ-carbon, γ-protonation can be a competing reaction in the case of the aliphatic substrates 12, 14b, 14d, and 18. The evidence is most consistent with a mechanism that involves proton transfer from 1a to a mixed aggregate consisting of enolate 4a and the lithiated amide 5, but direct proton transfer from 1a to the enolate is not ruled out.
VINYL RADICAL INDUCED MICHAEL ADDITIONS: TOTAL SYNTHESIS OF (+/-)-SEYCHELLENE
Bhaskar, Vijaya K.,Rao, Subba G. S. R.
, p. 225 - 228 (2007/10/02)
A new strategy for the total synthesis of (+/-)-seychellene which involves (i) a regiospecific construction of a bicyclo(2.2.2)octene moiety having a methyl group at the bridgehead and (ii) a vinyl radical induced intramolecular Michael addition is descri
