316805-01-3

Basic information

• Product Name: 1-hydroxymethyl-3-(4-methoxyphenyl)-5-methylpyrazole
• Synonyms: 1-hydroxymethyl-3-(4-methoxyphenyl)-5-methylpyrazole
• CAS NO: 316805-01-3
• Molecular Weight: 218.255
• Mol File: 316805-01-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-hydroxymethyl-3-(4-methoxyphenyl)-5-methylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-hydroxymethyl-3-(4-methoxyphenyl)-5-methylpyrazole(316805-01-3)
• EPA Substance Registry System: 1-hydroxymethyl-3-(4-methoxyphenyl)-5-methylpyrazole(316805-01-3)

Safety Data

• Hazardous Substances Data: 316805-01-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 23263-96-9 3-(4-methoxyphenyl)-5-methyl-1H-pyrazole 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 4023-80-7 1-(4-methoxyphenyl)butan-1,3-dione 

Downstream Products

• 145353-52-2 3-(4-hydroxyphenyl)-5-methyl-1H-pyrazole 
• 316804-99-6 tris[3-(4-methoxyphenyl)-5-methylpyrazol-1-ylmethyl]amine 

Relevant articles and documents

Synthesis of aryl-substituted or aryl-fused N-hydroxyethyl and N-hydroxymethypyrazole derivatives as potential ligands for the estrogen receptor

A new series of N-hydroxyethylpyrazole (12a-f) and N-hydroxymethylpyrazole derivatives (15a-f) were designed for their estrogenic activities, having a 11.0 ± 0.5 A distance between their two hydroxyl groups, aliphatic-OH and phenolic-OH similar to 17β-estradiol (E2) as an endogenous hormone. To synthesize the title compounds, the key intermediate 1,3-dicarbonyl derivatives (2 and 8), were treated with hydrazine hydrate to produce the pyrazole ring 5 and 9. Further hydroxyalkylation of the latter produced the title pyrazoles. The position of hydroxyethyl or hydroxymethyl substituents in the products was determined through 2D NOE NMR spectroscopy.