3169-76-4Relevant articles and documents
Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents
Mishra, Amita,Batchu, Harikrishna,Srivastava, Kumkum,Singh, Pratiksha,Shukla, Pravin K.,Batra, Sanjay
, p. 1719 - 1723 (2014)
Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to discover that several compounds displayed 2-3 folds better efficacy than chloroquine in chloroquine-resistant K1 strain of Plasmodium falciparum. Further, a few members of the library displayed good antibacterial efficacy against gram positive strains of bacteria but none of the compounds displayed any significant antifungal activity.