31699-02-2

Basic information

• Product Name: 2-methyl-5-(4-nitrophenyl)-1,3-oxazole
• Synonyms: oxazole, 2-methyl-5-(4-nitrophenyl)-
• CAS NO: 31699-02-2
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.1821
• Mol File: 31699-02-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 350.3°C at 760 mmHg
• Flash Point: 165.7°C
• Density: 1.285g/cm³
• Vapor Pressure: 8.95E-05mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2-methyl-5-(4-nitrophenyl)-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-5-(4-nitrophenyl)-1,3-oxazole(31699-02-2)
• EPA Substance Registry System: 2-methyl-5-(4-nitrophenyl)-1,3-oxazole(31699-02-2)

Safety Data

• Hazardous Substances Data: 31699-02-2(Hazardous Substances Data)

Usage

Description

2-methyl-5-(4-nitrophenyl)-1,3-oxazole is a chemical compound with the molecular formula C10H8N2O3. It is an oxazole derivative, which is a five-membered aromatic ring with one oxygen and one nitrogen atom, and a methyl and a nitrophenyl group attached to it. 2-methyl-5-(4-nitrophenyl)-1,3-oxazole is commonly used in organic synthesis and pharmaceutical research.

Uses

Used in Pharmaceutical Research:
2-methyl-5-(4-nitrophenyl)-1,3-oxazole is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable target for drug development and medicinal chemistry.
Used in Organic Synthesis:
2-methyl-5-(4-nitrophenyl)-1,3-oxazole is used as a building block in the synthesis of complex organic molecules. Its versatile reactivity and functional groups allow for the formation of a wide range of chemical products.
Used in Drug Development:
2-methyl-5-(4-nitrophenyl)-1,3-oxazole has been studied for its potential biological activities, including anti-inflammatory, antimicrobial, and antitumor properties. Its promising therapeutic potential makes it an important candidate for further research and development in the field of chemical and pharmaceutical sciences.

Upstream product

• 3969-09-3 2-methyl-5-phenyl-1,3-oxazole 
• 1846-34-0 N-(p-nitrophenacyl)acetamide 
• 855841-15-5 2-methyl-5-(4-nitro-phenyl)-oxazole-4-carboxylic acid 
• 4203-31-0 2-diazo-1-(4-nitrophenyl)ethanone 
• 75-05-8 acetonitrile 
• 3123-13-5 N-[1-hydroxymethyl-2-(4-nitro-phenyl)-2-oxo-ethyl]-acetamide 
• 6627-80-1 N-[1-(4-nitro-benzoyl)-vinyl]-acetamide 
• 855929-54-3 N-[2,2-dibromo-1-(4-nitro-benzoyl)-vinyl]-acetamide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 56177-37-8 1-(4-nitrophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 302-72-7 rac-Ala-OH 

Relevant articles and documents

METHOD FOR PRODUCING OXAZOLE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing an oxazole compound which makes it possible to obtain an oxazole compound inexpensively and safely. SOLUTION: A ketone compound, a nitrile compound, an iodinating agent, an oxidizing agent and an acid catalyst are mixed for a reaction to obtain an oxazole compound. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPOandINPIT

One-pot preparation of 2,5-disubstituted and 2,4,5-trisubstituted oxazoles from aromatic ketones with molecular iodine, oxone, and trifluoromethanesulfonic acid in nitriles

Alkyl aryl ketones were successfully converted into the corresponding 2,5-disubstituted and 2,4,5-trisubstituted oxazoles in good to moderate yields in a one-pot manner, utilizing iodine, Oxone, and trifluoromethanesulfonic acid in nitriles under transition-metal-free conditions. The present method could be used for the preparation of Oxaprozin from benzyl phenyl ketone and succinonitrile. A possible reaction mechanism was proposed in which the key intermediates were α-iodoalkyl aryl ketones and α-iodosylalkyl aryl ketones.

Synthesis of highly substituted oxazoles through iodine(III)-mediated reactions of ketones with nitriles

In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethanesulfonyl) imide (Tf2NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a single step under the mild conditions.