31784-70-0

Basic information

• Product Name: THIAZOLO[5,4-B]PYRIDIN-2-AMINE
• Synonyms: THIAZOLO[5,4-B]PYRIDIN-2-AMINE;[1,3]THIAZOLO[5,4-B]PYRIDIN-2-AMINE;2-AMINOTHIAZOLO[5,4-B]PYRIDINE ;Thiazolo[5,4-b]pyridin-2-ylamine
• CAS NO: 31784-70-0
• Molecular Formula: C₆H₅N₃S
• Molecular Weight: 151.19
• Mol File: 31784-70-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 252-254℃ (ethanol )
• Boiling Point: 328.9ºC at 760 mmHg
• Flash Point: 152.7ºC
• Appearance: /
• Density: 1.485g/cm3
• Vapor Pressure: 0.000184mmHg at 25°C
• Refractive Index: 1.785
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.09±0.40(Predicted)
• CAS DataBase Reference: THIAZOLO[5,4-B]PYRIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: THIAZOLO[5,4-B]PYRIDIN-2-AMINE(31784-70-0)
• EPA Substance Registry System: THIAZOLO[5,4-B]PYRIDIN-2-AMINE(31784-70-0)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 31784-70-0(Hazardous Substances Data)

Usage

General Description

Thiazolo[5,4-b]pyridin-2-amine is a heterocyclic compound with a fused ring structure containing both a thiazole and pyridine ring. This chemical compound is also known by the chemical name 1,3-thiazolo[5,4-b]pyridin-2-amine. It is a potential building block for the synthesis of various biologically active molecules and pharmaceuticals due to its unique structural features. Thiazolo[5,4-b]pyridin-2-amine has been studied for its potential medicinal properties, including its antiviral and antitumor activities. Its diverse reactivity and potential pharmacological properties make it an interesting target for medicinal chemistry research and pharmaceutical development.

InChI:InChI=1/C6H5N3S/c7-6-9-4-2-1-3-8-5(4)10-6/h1-3H,(H2,7,9)

Upstream product

• 67446-36-0 3-nitro-[2]pyridylsulfanyl cyanate 
• 6298-19-7 2-chloro-3-aminopyridine 
• 333-20-0 potassium thioacyanate 
• 117087-46-4 1-(2-chloropyridyl-3)-4-ethoxycarbonyl thiosemicarbazide 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 117087-45-3 (2-chloropyridin-3-yl)hydrazine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 17356-08-0 thiourea 
• 742640-87-5 N-thiazolo[5,4-b]pyridin-2-yl-benzamide 

Downstream Products

• 38240-21-0 2-mercapto-3-amino pyridine 
• 412923-40-1 2-bromothiazolo[5,4-b]pyridine 
• 865663-84-9 (6-iodo-quinazolin-4-yl)-thiazolo[5,4-b]pyridin-2-yl-amine 
• 1258527-36-4 C₃₃H₃₄FN₅O₃S 
• 1021164-79-3 2-(2,6-Dichlorophenyl)-1H-indole-6-carboxylic acid thiazolo[5,4-b]pyridin-2-ylamide 
• 50621-23-3 phenyl thiazolo[5,4-b]pyridin-2-ylcarbamate 
• 1280215-13-5 C₁₄H₁₂N₄OS 
• 1280215-17-9 C₁₃H₇Cl₃N₄OS 
• 1280215-18-0 C₁₃H₉BrN₄OS 
• 1280215-19-1 C₁₃H₉ClN₄OS 
• 1280215-21-5 C₁₄H₁₂N₄OS 
• 1280215-22-6 C₁₄H₁₂N₄OS 
• 1280215-28-2 C₁₃H₉N₅O₃S 

Relevant articles and documents

Hydrazone-based derivative, intermediate, preparation method, pharmaceutical composition and applications thereof

The present invention discloses a hydrazone-based derivative (I), an intermediate, a preparation method, a pharmaceutical composition and applications thereof, wherein the hydrazone-based compound hasgood inhibitory effect on the ubiquitination activity of cIAP1 protein, can promote the degradation of oncogenic protein c-MYC at a cellular level so as to inhibit the growth of tumor cells, and hasbroad drug development prospects.

POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR PRODUCING POLYMERIZABLE COMPOUND

A polymerizable compound has a practical low melting point, excellent solubility in a general-purpose solvent, and can produce an optical film at low cost, exhibits low reflected luminance, and achieves uniform conversion of polarized light over a wide wavelength band, an optically anisotropic article. A carbonyl compound is useful as a raw material for producing the polymerizable compound. (In the formula (I), Y1 to Y8 represent —C(═O)—O—, G1 and G2 represent a C1-20 divalent linear aliphatic group, Z1 and Z2 represent a C2-10 alkenyl group that is unsubstituted, or substituted with a halogen atom, Ax represents a C2-30 organic group with at least one aromatic ring, Ay represents a hydrogen atom or C1-20 alkyl group, A1 represents a trivalent aromatic group, A2 and A3 represent a C3-30 divalent alicyclic hydrocarbon group, A4 and A5 represent a C6-30 divalent aromatic group or the like, and Q1 represents a hydrogen atom.)

A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas

(Chemical Equation Presented) A one-step synthesis of thiazolo[5,4-b] pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6-nitrothiazo