31791-98-7

Basic information

• Product Name: Benzamide, N-hydroxy-3-methoxy-
• CAS NO: 31791-98-7
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Mol File: 31791-98-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzamide, N-hydroxy-3-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-hydroxy-3-methoxy-(31791-98-7)
• EPA Substance Registry System: Benzamide, N-hydroxy-3-methoxy-(31791-98-7)

Safety Data

• Hazardous Substances Data: 31791-98-7(Hazardous Substances Data)

Upstream product

• 1711-05-3 m-anisoyl chloride 
• 1426580-56-4 N-(2,3-dimethylbut-2-enyloxy)-3-methoxybenzamide 
• 38489-80-4 3-methoxybenzaldehyde oxime 
• 1050825-94-9 C₁₅H₁₅NO₃ 
• 586-38-9 3-Methoxybenzoic acid 
• 10259-22-0 ethyl 3-methoxybenzoate 
• 5368-81-0 methyl 3-methoxybenzoate 

Downstream Products

• 536-90-3 m-Anisidine 
• 1414350-91-6 3-methoxy-N-(pivaloyloxy)benzamide 
• 1610376-23-2 5-methoxy-N-(pivaloyloxy)-2-((triisopropylsilyl)ethynyl)benzamide 
• 1610376-24-3 3-methoxy-N-(pivaloyloxy)-2-((triisopropylsilyl)ethynyl)benzamide 
• 1394836-82-8 5-methoxy-1-(3-methoxybenzoyl)benzo[c]isoxazol-3(1H)-one 
• 64125-01-5 5-methoxycarbonylmethyl-3-(3-methoxy-phenyl)-[1,4,2]dioxazole-5-carboxylic acid methyl ester 
• 1038403-95-0 O-acetyl-3-methoxybenzohydroxamic acid 

Relevant articles and documents

Rhodium(III)-catalyzed C4-amidation of indole-oximes with dioxazolones: Via C-H activation

A novel method for the Rh(III)-catalyzed oxime-directed C-H amidation of indoles with dioxazolones has been developed. This strategy provides an exclusive site selectivity and the directing group can be easily removed. This transformation features a wide substrate scope, good functional group tolerance and excellent yields, and may serve as a significant tool to construct structurally diverse indole derivatives for the screening of potential pharmaceuticals in the future. This journal is

Experimental and computational studies on H2O-promoted, Rh-catalyzed transient-ligand-free ortho-C(sp2)-H amidation of benzaldehydes with dioxazolones

An efficient and convenient ligand-free, rhodium-catalyzed ortho-C(sp2)-H amidation of benzaldehydes with dioxazolones using H2O as the key promoter is described. Using this protocol, a wide range of benzaldehyde substrates were selectively amidated in good to excellent yields with broad functional group compatibility. KIE experiments revealed that the C-H bond activation was likely the rate-limiting step. In addition, computational studies indicated that the catalyst precursor interacted with water and dioxazolones to generate the active catalytic species. Notably, the practicality and efficacy of this method were illustrated by a late-stage amidation of an estrone-derived molecule and further transformations of the amidated product.

Rhodium-catalyzed C-H alkynylation of arenes at room temperature

The rhodium(III)-catalyzed ortho C-H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation. Hot rhod: A rhodium-catalyzed, electronically reversed Sonogashira reaction between unbiased arenes and the hypervalent iodine reagent 1 proceeds through C-H activation. This reaction displays excellent functional-group tolerance and high efficiency, and thus opens a new synthetic pathway to access functionalized alkynes. Cp=C5Me5, DCE=1,2-dichloroethane, Piv=pivaloyl, TIPS=triisopropylsilyl.