31827-04-0

Basic information

• Product Name: 3-HYDROXYINDOLE-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: METHYL 3-HYDROXYINDOLE-2-CARBOXYLATE;3-HYDROXY-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER;3-HYDROXYINDOLE-2-CARBOXYLIC ACID METHYL ESTER;RARECHEM AH BS 0107;3-HO-ICA-OMe;methyl 3-hydroxy-2-indolecarboxylate;Methyl indoxyl-2-carboxylate;methyl 3-hydroxy-1H-indole-2-carboxylate
• CAS NO: 31827-04-0
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.18
• Product Categories: Indole Derivatives
• Mol File: 31827-04-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 360.516°C at 760 mmHg
• Flash Point: 171.834°C
• Appearance: /
• Density: 1.383
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.679
• Storage Temp.: 2-8°C
• Solubility: Methanol
• CAS DataBase Reference: 3-HYDROXYINDOLE-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXYINDOLE-2-CARBOXYLIC ACID METHYL ESTER(31827-04-0)
• EPA Substance Registry System: 3-HYDROXYINDOLE-2-CARBOXYLIC ACID METHYL ESTER(31827-04-0)

Safety Data

• Hazardous Substances Data: 31827-04-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Methyl 3-Hydroxyindole-2-carboxylate (cas# 31827-04-0) is a compound useful in organic synthesis.

InChI:InChI=1/C10H9NO3/c1-14-10(13)8-9(12)6-4-2-3-5-7(6)11-8/h2-5,11-12H,1H3

Upstream product

• 64-17-5 ethanol 
• 100-63-0 phenylhydrazine 
• 2922-10-3 2-methoxycarbonylisatogen 
• 13622-59-8 N-(2-methoxycarbonylphenyl)glycine methyl ester 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 7732-18-5 water 
• 35757-92-7 dimethyl phenylaminomalonate 
• 612-42-0 phenylglycine-o-carboxylic acid 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 210117-43-4 3-(3,9-Dioxo-2,3-dihydro-1H,9H-pyrrolo[1,2-a]indol-9a-yl)-propionic acid benzyl ester 
• 138043-75-1 methyl 3-phenyl-1H-indole-2-carboxylate 
• 213881-58-4 methyl 1-benzyl-3-hydroxy-1H-2-indolecarboxylate 
• 213881-70-0 methyl 1-benzyl-3-phenyl-1H-2-indolecarboxylate 
• 213881-69-7 1-benzyl-3-(tert-butyl-dimethyl-silanyloxy)-1H-indole-2-carboxylic acid methyl ester 
• 213881-59-5 methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate 
• 1305155-35-4 methyl-2-(3-methyl-1H-indol-2-yl)-3-oxoindoline-2-carboxylate 

Relevant articles and documents

Improved scalable synthesis and biological activity of “indoxyl-gal,” a chromogenic histochemical used for the identification of lac+ organisms

An improved and operationally simple synthesis of 3-indoxyl-β-D-galactopyranoside (in-doxyl-gal) is disclosed. Indoxyl-gal is a sensitive chromogenic histochemical used for the identification of β-galactosidase enzymatic activity (lacZ gene). Synthesis of indoxyl-gal is improved to 25% overall yield in 5 linear steps from affordable starting materials with minimal chromatography. Biological testing confirmed the detection of β-galactosidase activity in all (100%, 19 strains) coliform bacteria using membrane filtration and modified MI agar.

3-substituted indole antiproliferative angiogenesis inhibitors

3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.