31828-68-9 Usage
Description
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE is a colorless solid that serves as a key intermediate in the synthesis of various biologically active compounds. It is a derivative of the amino acid homocysteine, featuring a thiolactone ring that can be readily opened to form substituted homocysteine analogs.
Uses
Used in Pharmaceutical Industry:
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE is used as a precursor for the preparation of substituted homocysteine analogs, which act as inhibitors of peptidylglycine α-amidating monooxygenase (PAM). This enzyme plays a crucial role in the post-translational processing of peptide hormones, and its inhibition can lead to the development of therapeutic agents for various diseases.
Additionally, L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE is used in the synthesis of (mercaptoacyl)alanylprolines, which are potent metalloprotease inhibitors. Metalloproteases are a class of enzymes involved in various physiological processes, including tissue remodeling, inflammation, and cell signaling. Inhibition of these enzymes can be beneficial in treating conditions such as arthritis, cancer, and neurodegenerative diseases.
Biochem/physiol Actions
L-Homocysteine thiolactone, an amine reactive agent, is used to study post-translational modification of proteins, especially at lysine residues.
Check Digit Verification of cas no
The CAS Registry Mumber 31828-68-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,8,2 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 31828-68:
(7*3)+(6*1)+(5*8)+(4*2)+(3*8)+(2*6)+(1*8)=119
119 % 10 = 9
So 31828-68-9 is a valid CAS Registry Number.
InChI:InChI=1/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1
31828-68-9Relevant articles and documents
COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS
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Page/Page column 45-49; 63, (2010/12/31)
The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.
