31863-04-4

Basic information

• Product Name: ethyl (2-methoxy-4-nitrophenyl)carbamate
• Synonyms: carbamic acid, N-(2-methoxy-4-nitrophenyl)-, ethyl ester; Ethyl (2-methoxy-4-nitrophenyl)carbamate
• CAS NO: 31863-04-4
• Molecular Formula: C₁₀H₁₂N₂O₅
• Molecular Weight: 240.2127
• Mol File: 31863-04-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 342.1°C at 760 mmHg
• Flash Point: 160.7°C
• Density: 1.325g/cm³
• Vapor Pressure: 7.72E-05mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: ethyl (2-methoxy-4-nitrophenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2-methoxy-4-nitrophenyl)carbamate(31863-04-4)
• EPA Substance Registry System: ethyl (2-methoxy-4-nitrophenyl)carbamate(31863-04-4)

Safety Data

• Hazardous Substances Data: 31863-04-4(Hazardous Substances Data)

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 97-52-9 2-methoxy-4-nitrophenylamine 

Downstream Products

• 31847-22-0 ethyl N-(2-methoxy-4-aminobenzene)carbamate 
• 57165-06-7 N-(4-amino-3-methoxyphenyl)methanesulfonamide 
• 308125-06-6 N-(2-methoxy-4-methanesulfonamido-benzen)-ethylcarbamate 
• 38880-75-0 (2-hydroxy-4-nitro-phenyl)-carbamic acid ethyl ester 

Relevant articles and documents

SUBSTITUTED P-DIAMINOBENZENE DERIVATIVES

The present invention relates to aniline derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.

Synthesis and antiproliferative activity of some variously substituted acridine and azacridine derivatives

A group of 9-substituted acridine and azacridine derivatives (m-AMSA analogues) were synthesised following classical procedures as potential antitumour agents with inhibitory effects on DNA topoisomerase II. Some were found to have noticeable cytotoxicity against human HL-60 and HeLa cells grown in culture. Their non-covalent interactions with calf thymus DNA have been studied using fluorescence quenching. We evaluated DNA damage produced by the tested compounds by means of DNA filter elution and protein precipitation techniques. Catalytic studies carried out with purified topoisomerase confirmed these agents as antitopoisomerase inhibitors. Chemotherapy of solid-tumour-bearing mice with tested compounds allowed an aza-analogue (compound IIIb), as potent as m-AMSA but less toxic towards the host, to be recognised. (C) 2000 Editions scientifiques et medicales Elsevier SAS.