318684-82-1 Usage
General Description
6,7-difluoroquinolin-3-amine is a chemical compound that belongs to the class of quinoline derivatives. It is a derivative of quinoline, a heterocyclic aromatic organic compound. 6,7-difluoroquinolin-3-amine contains two fluorine atoms on the 6th and 7th positions of the quinoline ring, as well as an amine group on the 3rd position. The presence of fluorine atoms in the molecule makes it potentially useful for pharmaceutical applications as fluorine is known to enhance the metabolic stability, lipophilicity, and binding affinity of organic compounds. The amine group also makes it a potential precursor for the synthesis of other biologically active molecules. As a result, 6,7-difluoroquinolin-3-amine has potential applications in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 318684-82-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,8,6,8 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 318684-82:
(8*3)+(7*1)+(6*8)+(5*6)+(4*8)+(3*4)+(2*8)+(1*2)=171
171 % 10 = 1
So 318684-82-1 is a valid CAS Registry Number.
318684-82-1Relevant articles and documents
Synthetic method of 3-amino-6,7-difluoroquinoline
-
, (2018/10/19)
The invention provides a synthetic method of 3-amino-6,7-difluoroquinoline. The synthetic method comprises the following steps: firstly, adding a solvent into glycerol, adding 3,4-difluoroaniline anda catalyst and heating and reacting to obtain 6,7-difluoroquinoline; secondly, slowly adding N-bromosuccinimide and the solvent into the 6,7-difluoroquinoline, heating and reacting to obtain 3-bromo-6,7-difluoroquinoline; thirdly, adding aminomethoxytert-butyl ester, the solvent and the catalyst into the 3-bromo-6,7-difluoroquinoline for reacting to obtain 3-N-t-butoxycarbonylamino-6,7-difluoroquinoline; fourthly, adding hydrochloric acid and the solvent into 3-N-t-butoxycarbonyl amino-6,7-difluoroquinoline for reacting to obtain 3-amino-6,7-difluoroquinoline. The synthetic method of the 3-amino-6,7-difluoroquinoline, disclosed by the invention, has the advantages of simple route, low-priced and easily-obtained raw materials, convenience in post treatment, high product yield and suitability for an enlargement synthetic route of the 3-amino-6,7-difluoroquinoline.
