3187-58-4

Basic information

• Product Name: METHYL ORSELLINATE
• Synonyms: Orsellinic acid methyl;6-Methyl-β-resorcylic acid methyl;Methyl o-orsellinate;o-Orsellinic acid methyl
• CAS NO: 3187-58-4
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.18
• Product Categories: Aromatic Esters
• Mol File: 3187-58-4.mol
• Article Data: 49

Chemical Properties

• Melting Point: 141-142℃
• Boiling Point: 339℃
• Flash Point: 138℃
• Appearance: /
• Density: 1.296
• Vapor Pressure: 4.8E-05mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• PKA: 8.27±0.23(Predicted)
• CAS DataBase Reference: METHYL ORSELLINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL ORSELLINATE(3187-58-4)
• EPA Substance Registry System: METHYL ORSELLINATE(3187-58-4)

Safety Data

• Hazardous Substances Data: 3187-58-4(Hazardous Substances Data)

Usage

Description

METHYL ORSELLINATE, also known as Methyl 2,4-Dihydroxy-6-methylbenzoate, is a synthetic intermediate with significant applications in the pharmaceutical industry. It is characterized by its unique chemical structure, which contributes to its various functionalities and potential uses.

Uses

Used in Pharmaceutical Industry:
METHYL ORSELLINATE is used as a synthetic intermediate for the production of Grifolic Acid (G786500), a selective partial GPR120 agonist. METHYL ORSELLINATE plays a crucial role in the development of drugs targeting specific receptors, which can be beneficial for treating various medical conditions.
Grifolic Acid, synthesized using METHYL ORSELLINATE, is known to induce ERK and [Ca2+]i responses in cells expressing GPR120. It does not have any effects on cells expressing GPR40, making it a selective agonist with potential therapeutic applications.

InChI:InChI=1/C9H10O4/c1-5-3-6(10)4-7(11)8(5)9(12)13-2/h3-4,10-11H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 60-29-7 diethyl ether 
• 480-64-8 orsellinic acid 
• 67-56-1 methanol 
• 480-56-8 lecanoric acid 
• 30666-92-3 umbilicaric acid 
• 548-89-0 gyrophoric acid 
• 106-99-0 buta-1,3-diene 
• 77-78-1 dimethyl sulfate 
• 860752-66-5 2,4-bis-methoxycarbonyloxy-6-methyl-benzoic acid 
• 74-88-4 methyl iodide 
• 674-82-8 4-methyleneoxetan-2-one 
• 105-45-3 acetoacetic acid methyl ester 
• 23066-87-7 methyl 3,5,7-trioxooctanoate 

Downstream Products

• 520-43-4 2-hydroxy-4-methoxy-6-methyl-benzoic acid methyl ester 
• 34874-90-3 methyl haematommate 
• 64400-53-9 methyl isohaematommate 
• 715-33-3 methyl 2,4-dihydroxy-3,5-dibromo-6-methylbenzoate 
• 19104-05-3 3,4,6-trihydroxy-2-methyl-benzoic acid methyl ester 
• 715-34-4 methyl 3,5-dichloro-2,4-dihydroxy-6-methylbenzoate 
• 856176-93-7 2-hydroxy-6-methyl-4-(toluene-4-sulfonyloxy)-benzoic acid methyl ester 
• 19802-83-6 3-acetyl-2,4-dihydroxy-6-methyl-benzoic acid methyl ester 
• 56157-28-9 6-methyl-2,4-diacetoxycarboxylic acid methyl ester 
• 34874-77-6 methyl 3,5-diformyl-2,4-dihydroxy-6-methylbenzoate 
• 80145-01-3 methyl 4-O-benzyl-2-O-methyllecanorate 
• 130998-50-4 2-Hydroxy-6-methyl-4-((3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-benzoic acid methyl ester 
• 118607-91-3 potassium methyl orsenillate 
• 103233-29-0 Methyl-2-hydroxy-6-methyl-4-pivaloyloxy-benzoat 

Relevant articles and documents

Chemical Studies on the Lichen. I. The Structure of Isolecanoric Acid, a New ortho-Depside Isolated from Parmelia tinctorum Despr.

A new ortho-depside, isolecanoric acid was isolated from Parmelia tinctorum Despr. and 2-(2,4-dihydroxy-6-methylbenzoyloxy)-4-hydroxy-6-methylbenzoic acid was assigned to this substance from studies on the hydrolysis products and from analyses of the 1H and 13C NMR spectra.This substance is the first ortho-depside isolated from the genus Lichen.

Photolytic Studies on the Generation and Trapping of 6-Oxomethylidenecyclohexa-2,4-diene-1-one Derivatives with Various Nucleophiles

α-Oxoketenes and cyclohexadiene α-oxoketenes are reactive intermediates, particularly the latter due to their high re-aromatization potential. In this communication, we report photolytic studies on the generation of such species from 4-OMe and 4-OMOM protected resorcylate dioxinones and their trapping to give resorcylate esters and amides as well as the formation of adducts with enol-ethers as trapping reagents.

CANNABIDIOL-TYPE CANNABINOID COMPOUND

The present invention relates to a cannabidiol (CBD) type cannabinoid compound for use as a medicament. The CBD-type cannabinoid, cannabidiol-C1 (CBD-C1), is a naturally occurring cannabinoid that can be found in minor quantities in the cannabis plant. Furthermore, the 5 cannabinoid can be produced by synthetic means and a method for the production of CBD-C1 is described herein. In addition, disclosed herein are data which demonstrate the efficacy of CBD-C1 in models of disease.