3187-94-8Relevant articles and documents
Dehydroxyalkylative halogenation of C(aryl)-C bonds of aryl alcohols
Liu, Mingyang,Zhang, Zhanrong,Liu, Huizhen,Wu, Tianbin,Han, Buxing
supporting information, p. 7120 - 7123 (2020/07/14)
We herein report Cu mediated side-directed dehydroxyalkylative halogenation of aryl alcohols. C(aryl)-C bonds of aryl alcohols were effectively cleaved, affording the corresponding aryl chlorides, bromides and iodides in excellent yields. Aryl alcohols could serve as both aromatic electrophilic and radical synthetic equivalents during the reaction.
Identification of compounds for the treatment or prevention of proliferative diseases
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Page 21, (2010/02/03)
The invention features compounds for the treatment of cancer and other proliferative diseases. These compounds were identified in screening assays that contact candidate compounds with a cell containing a nucleic acid that includes a HER2 regulatory element and a reporter sequence. The invention further features compounds structurally related to those identified by the screening assays. Finally, the invention features methods of treating or preventing a proliferative disease using the compounds of the invention.
Preparation of 2-Chlorofuran and 2-Chlorothiophene from the Respective Furan and Thiophene Mercurials and Disulfur Dichloride
Khodeir, Mohammed N. M.,Skulski, Lech,Wroczynski, Piotr
, p. 443 - 448 (2007/10/02)
2-Chloro- and 2-iodo-substituted furans and thiophenes (with no admixture of higher halogenated products) have been obtained from 2,2'-difurylmercury or 2,2'-dithienylmercury by the action of either a solution of freshly-redistilled S2Cl2 in carbon disulfide or an aqueous solution of KI3, in 60-70percent isolated yields. 2-Chlorofuran and 2-chlorothiophene may also be obtained by the direct action of either furan or thiophene on a mixture of HgCl2 and S2Cl2, in 50percent and 60percent isolated yields, respectively.
