31872-98-7Relevant articles and documents
2-Amino-5-methyl-5-hexenoic acid, a methionine analog produced by Streptomyces sp. MF374-C4
Takeuchi,Iinuma,Takeuchi,Umezawa
, p. 1118 - 1124 (1979)
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Resolution of non-protein amino acids via microbial protease-catalyzed ester hydrolysis: Marked enhancement of enantioselectivity by the use of esters with longer alkyl chains and at low temperature
Miyazawa, Toshifumi,Minowa, Hiroe,Miyamoto, Toyoko,Imagawa, Kiwamu,Yanagihara, Ryoji,Yamada, Takashi
, p. 367 - 370 (2007/10/03)
In the microbial protease-catalyzed hydrolysis of amino acid esters with the free α-amino group, the enantioselectivity can be enhanced greatly by employing esters with longer alkyl chains such as the isobutyl ester instead of the conventional methyl ester and by conducting the reaction at low temperature.
1,2-Bis(diphenylphosphino)-1-cyclohexylethane. A New Chiral Phosphine Ligand for Catalytic Chiral Hydrogenations
Riley, Dennis P.,Shumate, Robert E.
, p. 5187 - 5193 (2007/10/02)
The new chiral bidentate phosphine ligand (R)-1,2-bis(diphenylphosphino)-1-cyclohexylethane ((R)-Cycphos) has been prepared.The rhodium(I) cationic complex of this phosphine serves as an effective homogeneous asymmetric hydrogenation catalyst for the reduction of (Z)-α-amidoacrylic acids at ambient temperature and pressure.Optical yields for the corresponding (S)-α-amino acid derivatives that are produced are generally above 90percent.The success of this ligand in giving higher optical yields than those obtained from other structurally analogous phosphines is rationalized in terms of the bulky cyclohexyl substituent affording a more stereochemically rigid chelating phosphine.