3188-46-3 Usage
Description
17BETA-ESTRADIOL-16,16-D2, also known as 17beta-Estradiol-16,16-d2, is an isotopically labeled research compound derived from the naturally occurring hormone estradiol. It possesses a deuterium atom at the 16th position on both A and B rings, which allows for the study of its interactions and effects in various biological systems. 17BETA-ESTRADIOL-16,16-D2 is widely used in scientific research to investigate the role of estradiol in various physiological processes and to develop new therapeutic strategies.
Uses
Used in Pharmaceutical Research:
17BETA-ESTRADIOL-16,16-D2 is used as a research compound for studying the effects of estradiol on various physiological processes. It helps researchers understand the molecular mechanisms underlying the action of estradiol and its role in hormone-related diseases.
Used in Drug Development:
17BETA-ESTRADIOL-16,16-D2 is used as a tool in the development of new drugs targeting hormone-related conditions. Its isotopically labeled nature allows for the tracking of its distribution, metabolism, and excretion in the body, providing valuable information for the optimization of drug candidates.
Used in Analytical Chemistry:
17BETA-ESTRADIOL-16,16-D2 is used as an internal standard or reference compound in the quantification of estradiol levels in biological samples. Its stable isotopic composition ensures accurate and reliable measurements, which are crucial for the diagnosis and monitoring of hormone-related disorders.
Used in Endocrinology Research:
17BETA-ESTRADIOL-16,16-D2 is used as a research tool in endocrinology to study the role of estradiol in the regulation of various physiological processes, such as reproductive function, bone metabolism, and cardiovascular health. 17BETA-ESTRADIOL-16,16-D2 helps researchers gain insights into the complex interactions between hormones and their target tissues.
Used in Toxicology Studies:
17BETA-ESTRADIOL-16,16-D2 is used in toxicology research to investigate the potential adverse effects of estradiol and its analogs on human health. Its isotopically labeled nature allows for the differentiation between endogenous and exogenous sources of estradiol, providing valuable information for the assessment of risk and the development of safety guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 3188-46-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,8 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3188-46:
(6*3)+(5*1)+(4*8)+(3*8)+(2*4)+(1*6)=93
93 % 10 = 3
So 3188-46-3 is a valid CAS Registry Number.
3188-46-3Relevant articles and documents
Biosynthesis of Estrogens. Estr-5(10)-ene-3,17-dione: Isolation, Metabolism and Mechanistic Implications
Ranjith, H.,Dharmaratne, W.,Kilgore, James L.,Roitman, Esther,Shackleton, Cedric,Caspi, Eliahu
, p. 1529 - 1536 (2007/10/02)
The 16-2H2 title compound 5b constituted a significant amount of the non-aromatic metabolites recovered from incubations of 3,17-dioxo-2H3>androst-4-en-19-al 1 with placental aromatase.For the evaluation of the role of compound 5b in the elaboration of estrogens, its transformations at pH 6.5 and 7.2 in the presence and absence of microsomal placental aromatase were investigated.In the presence of the aromatase at pH 6.5, estrogens (6.8percent), products of isomerization of the double bond (Δ5(10) -> Δ4) and products of reduction of the carbonyl groups were formed.When the incubation was carried out at pH 7.2, products similar to those obtained above were isolated but in different yields.Noticeably more estrogens (22.7percent) and less of the reduced products were formed.Additionally, at pH 7.2, 10β-hydroxy-2H2>estr-4-ene-3,17-dione 4a was obtained.In the absence of the aromatase, which was replaced with bovine albumin at both pH 6.5 and 7.2, 2H2>estr-4-ene-3,17-dione 3a and its 10β-hydroxy derivative 4a were formed in large amounts and were the only products detected.The ramifications of our observations in the context of estrogen biosynthesis are discussed.
