3189-48-8 Usage
Description
INDOLIZINE-2-CARBOXYLIC ACID is an organic compound with the molecular formula C9H7NO2. It is a white crystalline solid and serves as a key building block in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile component in the development of new drugs and therapeutic agents.
Uses
Used in Pharmaceutical Industry:
INDOLIZINE-2-CARBOXYLIC ACID is used as a key intermediate for the synthesis of acylaminophenyloxazoles, which are known as inosine monophosphate dehydrogenase inhibitors. These inhibitors play a crucial role in the development of antiviral and anticancer drugs, as they help regulate the activity of enzymes involved in nucleotide synthesis and immune response modulation.
INDOLIZINE-2-CARBOXYLIC ACID is also used as a starting material for the synthesis of indolizine-2-carboxamides. These compounds have potential applications as HIV-1 protease inhibitors, which are essential in the treatment of HIV/AIDS. By inhibiting the activity of the HIV-1 protease enzyme, these compounds can help prevent the replication of the virus and slow down the progression of the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 3189-48-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,8 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3189-48:
(6*3)+(5*1)+(4*8)+(3*9)+(2*4)+(1*8)=98
98 % 10 = 8
So 3189-48-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7NO2/c11-9(12)7-5-8-3-1-2-4-10(8)6-7/h1-6H,(H,11,12)
3189-48-8Relevant articles and documents
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Wiley,Knabeschuh
, p. 836,839 (1953)
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Propylphosphonic acid anhydride–mediated amidation of Morita–Baylis–Hillman–derived indolizine-2-carboxylic acids
Sekgota, Khethobole C,Isaacs, Michelle,Hoppe, Heinrich C,Seldon, Ronnett,Warner, Digby F,Khanye, Setshaba D,Kaye, Perry T
, p. 674 - 678 (2021/03/31)
Propylphosphonic acid anhydride has been successfully used as a coupling agent in the synthesis of a series of indolizine-2-carboxamido derivatives from indolizine-2-carboxylic acid and its 3-acetylated analogue. The acid substrates were obtained by sapon
NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
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Page/Page column 125-126; 146, (2020/11/12)
The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
