31898-49-4

Basic information

• Product Name: N-{[2-(5-nitrofuran-2-yl)-1,3-thiazol-4-yl]methylidene}thiomorpholin-4-amine 1,1-dioxide
• Synonyms: 4-thiomorpholinamine, N-[[2-(5-nitro-2-furanyl)-4-thiazolyl]methylene]-, 1,1-dioxide; N-{[2-(5-Nitro-2-furyl)-1,3-thiazol-4-yl]methylene}thiomorpholin-4-amine 1,1-dioxide
• CAS NO: 31898-49-4
• Molecular Formula: C₁₂H₁₂N₄O₅S₂
• Molecular Weight: 356.3775
• Mol File: 31898-49-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 681.8°C at 760 mmHg
• Flash Point: 366.2°C
• Density: 1.72g/cm³
• Vapor Pressure: 1.91E-18mmHg at 25°C
• Refractive Index: 1.755
• CAS DataBase Reference: N-{[2-(5-nitrofuran-2-yl)-1,3-thiazol-4-yl]methylidene}thiomorpholin-4-amine 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{[2-(5-nitrofuran-2-yl)-1,3-thiazol-4-yl]methylidene}thiomorpholin-4-amine 1,1-dioxide(31898-49-4)
• EPA Substance Registry System: N-{[2-(5-nitrofuran-2-yl)-1,3-thiazol-4-yl]methylidene}thiomorpholin-4-amine 1,1-dioxide(31898-49-4)

Safety Data

• Hazardous Substances Data: 31898-49-4(Hazardous Substances Data)

Upstream product

• 59-84-7 5-nitrofuran-2-carbothioamide 
• 31898-51-8 [2-(5-nitro-furan-2-yl)-thiazol-4-yl]-methanol 

Relevant articles and documents

Antiprotozoal thiazoles. 2. 2 (5 Nitro 2 furyl-, thiazolyl-, and 1 methylimidazolyl-)thiazoles

Ten 2 substituted 4 thiazolecarboxaldehyde hydrazones bearing 5 nitro 2 furyl, 5 nitro 2 thiazolyl, and 1 methyl 5 nitro 2 imidazolyl functions have been prepared and screened for activity against Trypanosoma cruzi infections in mice. The results permitted the ranking of these substituents in decreasing order of activity: 1 methyl 5 nitro 2 imidazolyl > 5 nitro 2 furyl > 5 nitro 2 thiazolyl, the last being inactive. Some structural features of the side chain necessary for optimum activity are discussed. The most active compound, 4 [[[2 (1 methyl 5 nitro 2 imidazolyl) 4 thiazolyl]methylene]amino]thiomorpholine 1,1 dioxide, compared favorably with the standard Nifurtimox against 3 recent clinical isolates of T. cruzi, including 1 with a high myocardial tissue infiltration.