31898-69-8Relevant articles and documents
Non-transpeptidase binding arylthioether β-lactams active against Mycobacterium tuberculosis and Moraxella catarrhalis
Beck, Tim N.,Lloyd, Dina,Kuskovsky, Rostislav,Minah, Jeanette,Arora, Kriti,Plotkin, Balbina J.,Green, Jacalyn M.,Boshoff, Helena I.,Barry, Clifton,Deschamps, Jeffrey,Konaklieva, Monika I.
, p. 632 - 647 (2015/01/30)
The prevalence of drug resistance in both clinical and community settings as a consequence of alterations of biosynthetic pathways, enzymes or cell wall architecture is a persistent threat to human health. We have designed, synthesized, and tested a novel
C4-Alkylthiols with activity against Moraxella catarrhalis and Mycobacterium tuberculosis
Kostova, Maya B.,Myers, Carey J.,Beck, Tim N.,Plotkin, Balbina J.,Green, Jacalyn M.,Boshoff, Helena I.M.,Barry III, Clifton E.,Deschamps, Jeffrey R.,Konaklieva, Monika I.
experimental part, p. 6842 - 6852 (2011/12/15)
Antimicrobial resistance represents a global threat to healthcare. The ability to adequately treat infectious diseases is increasingly under siege due to the emergence of drug-resistant microorganisms. New approaches to drug development are especially nee
Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors
Clemente,Domingos,Grancho,Iley,Moreira,Neres,Palma,Santana,Valente
, p. 1065 - 1068 (2007/10/03)
A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the β-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and f
