318989-78-5

Basic information

• Product Name: Benzoic acid, 4-(4-morpholinyl)-, 1,1-dimethylethyl ester
• CAS NO: 318989-78-5
• Molecular Formula: C15H21NO3
• Molecular Weight: 263.337
• Mol File: 318989-78-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(4-morpholinyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(4-morpholinyl)-, 1,1-dimethylethyl ester(318989-78-5)
• EPA Substance Registry System: Benzoic acid, 4-(4-morpholinyl)-, 1,1-dimethylethyl ester(318989-78-5)

Safety Data

• Hazardous Substances Data: 318989-78-5(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 712-95-8 tert-butyl 4-chlorobenzoate 
• 63631-26-5 C₃₃H₃₉O₁₀P 
• 59247-47-1 tert-butyl-4-bromobenzoate 

Relevant articles and documents

Buchwald-Hartwig aminations of aryl chlorides: A practical protocol based on commercially available Pd(0)-NHC catalysts

Commercially available, air- and water-stable naphthoquinone imidazolin-2-ylidene-palladium(0) complexes were found to be highly active one-component catalysts for the amination of aryl halides. With these very robust catalysts, the expensive bases Cs2CO3 or NaOt-Bu traditionally used can be replaced by KOH. A convenient reaction protocol has been developed for the coupling of a wide range of aryl chlorides with primary or secondary amines.

Nickel-catalyzed amination of aryl phosphates through cleaving aryl C-O bonds

The amination of triaryl phosphates was achieved using a Ni(II)-(σ-Aryl) complex/NHC catalyst system in dioxane at 110 °C in the presence of NaH as base. Electron-neutral, -rich, and -deficient triaryl phosphates were coupled with a wider range of amine partners including cyclic and acyclic secondary amines, aliphatic primary amines, and anilines in good to excellent yields.