319-72-2 Usage
Description
4-(5-FLUORO-1H-INDOL-3-YL)-BUTYRIC ACID is a chemical compound that features a 5-fluoro-1H-indol-3-yl group attached to a butyric acid backbone. This molecule is characterized by the presence of a fluorine atom at the 5-position of the indole ring, which can influence its biological activity and properties. It is a versatile building block in the synthesis of various pharmaceutical agents and has potential applications in the development of therapeutics for serotonin-mediated disorders.
Uses
Used in Pharmaceutical Industry:
4-(5-FLUORO-1H-INDOL-3-YL)-BUTYRIC ACID is used as a key intermediate in the synthesis of Aminochroman and Aminotetralin derivatives. These derivatives are known for their potential therapeutic effects in the treatment of serotonin-mediated disorders, such as depression, anxiety, and other mood-related conditions. The presence of the fluorine atom in the indole ring may contribute to the modulation of serotonin receptor activity, leading to improved treatment outcomes.
In the synthesis of these derivatives, 4-(5-FLUORO-1H-INDOL-3-YL)-BUTYRIC ACID serves as a crucial component, providing a structural foundation that can be further modified to create a variety of bioactive molecules. Its use in the pharmaceutical industry highlights the importance of fluorinated compounds in drug discovery and development, as they can offer unique advantages in terms of selectivity, potency, and metabolic stability.
Check Digit Verification of cas no
The CAS Registry Mumber 319-72-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 319-72:
(5*3)+(4*1)+(3*9)+(2*7)+(1*2)=62
62 % 10 = 2
So 319-72-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H12FNO2/c13-9-4-5-11-10(6-9)8(7-14-11)2-1-3-12(15)16/h4-7,14H,1-3H2,(H,15,16)
319-72-2Relevant articles and documents
Deciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations
Park, Soyoung,Ikehata, Keiichi,Watabe, Ryo,Hidaka, Yuta,Rajendran, Arivazhagan,Sugiyama, Hiroshi
supporting information, p. 10398 - 10400,3 (2020/09/09)
We describe asymmetric intramolecular Friedel-Crafts alkylations with a DNA-based hybrid catalyst and propose a plausible binding model. This study shows promise for studying relationships between the helical chirality of DNA and enantioselectivity of the chemical reaction.
3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES
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Page/Page column 78, (2010/02/10)
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.
