31925-27-6Relevant articles and documents
Synthesis method of D-p-methylsulfonylphenyl serine ethyl ester
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Paragraph 0008-0009, (2020/01/25)
The invention discloses a synthesis method of D-p-methylsulfonyl phenyl serine ethyl ester. The method comprises the following steps: preparing p-methylsulfonylphenylserine copper by taking p-methylsulfonylbenzaldehyde, copper sulfate and glycine as main raw materials; then adding anhydrous ethanol and concentrated sulfuric acid into an esterification reaction kettle, carrying out heating for a reaction, filtering out copper sulfate while the solution is hot, carrying out cooling for crystallizing, and carrying out filtering to obtain DL p-methylsulfonylphenyl serine ethyl ester sulfate, dissolving the DL p-methylsulfonylphenyl serine ethyl ester sulfate into water, removing copper ions by using a saturated sodium sulfide solution, adding an alkali into the mother solution for dissociationto obtain DL p-methylsulfonylphenyl serine ethyl ester, and adding a resolving agent for resolving to obtain a product. The method is simple in process, high in yield, low in cost and small in environmental pollution and is suitable for enterprise production.
P-Methyl sulfone phenyl ethyl serinate and synthetic method thereof
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Paragraph 0017; 0040; 0045-0059, (2018/09/12)
The invention discloses a synthetic method of P-methyl sulfone phenyl ethyl serinate, comprising the steps of S1, adding ethyl glycinate hydrochloride into methanol, and heating to dissolve to form afirst solution; S2, adding copper sulfate pentahydrate in the first solution to form a second solution by dissolving; S3, adjusting PH value of the second solution to meet the condition for alkaline reaction, adding P-methylsufonyl benzaldehyde to allow reaction, and holding the temperature and controlling the PH value to keep reaction condition values during reaction; S4, recycling methanol in the reacted materials, adding water to the residue to form a third solution, cooling, and centrifugally separating to obtain P-methyl sulfone phenyl ethyl serinate. The ethyl glycinate hydrochloride andP-methylsufonyl benzaldehyde are subjected to further reaction under the catalytic action of copper sulfate and an organic base to generate a target product; no sulfuric acid is used in the reactionprocess, the amount of waste acid in waste water is decreased, and the environment is protected; dangers that may occur during sulfuric acid transport and production are avoided, better safety is provided, and operating efficiency can be improved.
