31970-26-0

Basic information

• Product Name: 4-iodopropiophenone
• Synonyms: 4-iodopropiophenone;1-(4-iodophenyl)propan-1-one
• CAS NO: 31970-26-0
• Molecular Formula: C₉H₉IO
• Molecular Weight: 260.08
• Mol File: 31970-26-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 54-55 °C
• Boiling Point: 294.6°Cat760mmHg
• Flash Point: 131.9°C
• Appearance: /
• Density: 1.63g/cm³
• Vapor Pressure: 0.00161mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 4-iodopropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodopropiophenone(31970-26-0)
• EPA Substance Registry System: 4-iodopropiophenone(31970-26-0)

Safety Data

• Hazardous Substances Data: 31970-26-0(Hazardous Substances Data)

Usage

Description

4-iodopropiophenone, with the molecular formula C9H9IO, is a pale yellow solid that exhibits a slightly sweet, floral odor. This chemical compound is recognized for its versatility in various industrial applications, particularly in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

Uses

Used in Pharmaceutical Synthesis:
4-iodopropiophenone is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its chemical properties make it a valuable component in the development of new medications.
Used in Agrochemical Production:
In the agrochemical sector, 4-iodopropiophenone serves as an intermediate in the production of various agrochemicals. Its role in this industry is crucial for the creation of effective products for agricultural use.
Used in Organic Reactions:
4-iodopropiophenone is utilized in organic reactions for the preparation of ketones and esters. Its reactivity and stability contribute to the synthesis of a range of organic compounds.
Safety Precautions:
It is important to handle 4-iodopropiophenone with care, as it can be harmful if ingested or inhaled, and it may cause irritation to the skin and eyes. Proper safety measures should be taken during its use to minimize potential health risks.

InChI:InChI=1/C9H9IO/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6H,2H2,1H3

Upstream product

• 591-50-4 iodobenzene 
• 79-03-8 propionyl chloride 
• 70-69-9 1-(4-aminophenyl)-1-propanone 
• 10342-83-3 4'-Bromopropiophenone 
• 13183-70-5 1,4-bis-(trimethylsilyl)benzene 
• 107134-72-5 [4-(dichloroboryl)phenyl]trimethylsilane 
• 6285-05-8 4'-chloropropiophenone 

Downstream Products

• 114401-75-1 5-(4-iodophenyl)-3H-1,2-dithiole-3-thione 
• 31867-48-8 2-bromo-1-(4-iodo-phenyl)-propan-1-one 
• 99059-63-9 1-(4-iodophenyl)-2-methyl-1-propanone 
• 90609-48-6 1-(4-iodophenyl)-1-propanol 
• 858783-43-4 3-(4-iodo-phenyl)-thiopropionic acid dimethylamide 
• 109567-30-8 N-[2-(4-iodo-phenyl)-1-methyl-2-oxo-ethyl]-phthalimide 
• 96217-73-1 Bernsteinsaeure-mono-<1-(4-iod-phenyl)-propylester> 
• 1245626-36-1 lithium 4-ehoxy-1-(4-iodophenyl)-2-methyl-3,4-dioxobut-1-en-1-olate 
• 1276030-93-3 (Z)-1-[4-(2-chloroethoxy)phenyl]-2-(4-iodophenyl)-1-phenylbut-1-ene 
• 1276030-97-7 (Z)-2-(4-iodophenyl)-1-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-1-phenylbut-1-ene 

Relevant articles and documents

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis

A high-throughput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberculosis (Mtb). The 11000 compounds were selected for the HTS based on the known phenothiazine Ndh inhibitors, trifluoperazine and thioridazine. Combined HTS (11000 compounds) and in-house screening of a limited number of quinolones (50 compounds) identified ～100 hits and four distinct chemotypes, the most promising of which contained the quinolone core. Subsequent Mtb screening of the complete in-house quinolone library (350 compounds) identified a further ～90 hits across three quinolone subtemplates. Quinolones containing the amine-based side chain were selected as the pharmacophore for further modification, resulting in metabolically stable quinolones effective against multi drug resistant (MDR) Mtb. The lead compound, 42a (MTC420), displays acceptable antituberculosis activity (Mtb IC50 = 525 nM, Mtb Wayne IC50 = 76 nM, and MDR Mtb patient isolates IC50 = 140 nM) and favorable pharmacokinetic and toxicological profiles.

Photo-induced Metal-Catalyst-Free Aromatic Finkelstein Reaction

The facile iodination of aromatic compounds under mild conditions is a great challenge for both organic and medicinal chemistry. Particularly, the synthesis of functionalized aryl iodides by light has long been considered impossible due to their photo-lability, which actually makes aryl iodides popular starting materials in many photo-substitution reactions. Herein, a photo-induced halogen exchange in aryl or vinyl halides has been discovered for the first time. A broad scope of aryl iodides can be prepared in high yields at room temperature under exceptionally mild conditions without any metal or photo-redox catalysts. The presence of a catalytic amount of elemental iodine could promote the reaction significantly.

NOVEL HETERO PYRROLE ANALOGS ACTING ON CANNAPINOID RECEPTORS

Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor