32016-25-4

Basic information

• Product Name: 7-amino-3,6-diphenylpyrazolo<1,5-a>pyrimidine
• Synonyms: 7-amino-3,6-diphenylpyrazolo<1,5-a>pyrimidine
• CAS NO: 32016-25-4
• Molecular Weight: 286.336
• Mol File: 32016-25-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 7-amino-3,6-diphenylpyrazolo<1,5-a>pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-amino-3,6-diphenylpyrazolo<1,5-a>pyrimidine(32016-25-4)
• EPA Substance Registry System: 7-amino-3,6-diphenylpyrazolo<1,5-a>pyrimidine(32016-25-4)

Safety Data

• Hazardous Substances Data: 32016-25-4(Hazardous Substances Data)

Upstream product

• 18226-53-4 2-phenyl-3-(piperidin-1-yl)acrylonitrile 
• 5591-70-8 4-phenyl-1H-pyrazol-3-ylamine 
• 57999-06-1 4-phenyl-1H-pyrazol-5-amine 
• 57488-21-8 (Z)-2-phenyl-3-(piperidin-1-yl)acrylonitrile 
• 5841-70-3 phenyl(formyl)acetonitrile 
• 7803-57-8 hydrazine hydrate 
• 64-19-7 acetic acid 

Downstream Products

• 79833-91-3 4,5-dihydro-3,6-diphenylpyrazolo<1,5-a>pyrimidine 

Relevant articles and documents

Development of 7-Aminopyrazolo[1,5-a]pyrimidines as Anti-Candida and Antibacterial Agents

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Studies with enaminonitriles: Synthesis and chemical reactivity of 2-phenyl-3-piperidin-1-yl acrylonitrile under microwave heating

(Chemical Equation Presented) Benzyl cyanide reacts with triethylorthoformate and piperidine in DMF solution to yield the title compound 2. This reacted with aromatic amines to yield either aminoacrylonitriles orquinoline depending on reaction conditions and substitution pattern on the aromatic amine. The reaction of compound 2 with hydrazine hydrate could only be effected in the microwave oven and resulted in the formation of aminopyrazole 7. Diazotization of 7 and coupling with an active methylene reagent afforded pyrazolo[5,1-c]-[1,2,4]triazine derivatives.