32025-37-9

Basic information

• Product Name: Benzoic acid, 2-(1-oxopropyl)-, methyl ester
• CAS NO: 32025-37-9
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Mol File: 32025-37-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-(1-oxopropyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(1-oxopropyl)-, methyl ester(32025-37-9)
• EPA Substance Registry System: Benzoic acid, 2-(1-oxopropyl)-, methyl ester(32025-37-9)

Safety Data

• Hazardous Substances Data: 32025-37-9(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 74-88-4 methyl iodide 
• 4397-55-1 phthalic monoacid monomethyl ester chloride 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 148761-93-7 1-(2-iodophenyl)-2-propen-1-ol 
• 2360-45-4 2-propanoylbenzoic acid 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 118836-67-2 2-(2-hydroxyimino-propionyl)-benzoic acid methyl ester 

Relevant articles and documents

Ruthenium-Catalyzed Enantioselective Hydrogenation/Lactonization of 2-Acylarylcarboxylates: Direct Access to Chiral 3-Substituted Phthalides

Highly enantioselective tandem hydrogenation/lactonization of various 2-acylarylcarboxylates including 2-aroylarylcarboxylates were realized by using [RuCl(benzene)(S)-SunPhos]Cl as the catalyst under mild reaction conditions. Excellent enantioselectivities (up to 99.6 % ee) and activities (S/C=1000) were obtained. This convenient and practical method enables a direct access to a series of highly optically pure 3-substituted phthalides that are very important molecules as valuable pharmacological compounds and diversified synthons for medicinal chemistry. Moreover, a gram-scale reaction was performed to further demonstrate the practicality of this approach.