32025-66-4

Basic information

• Product Name: 3-methoxy-4-hydroxyphenylglyoxal
• Synonyms: 3-methoxy-4-hydroxyphenylglyoxal
• CAS NO: 32025-66-4
• Molecular Weight: 180.16
• Mol File: 32025-66-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-methoxy-4-hydroxyphenylglyoxal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-4-hydroxyphenylglyoxal(32025-66-4)
• EPA Substance Registry System: 3-methoxy-4-hydroxyphenylglyoxal(32025-66-4)

Safety Data

• Hazardous Substances Data: 32025-66-4(Hazardous Substances Data)

Upstream product

• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 50597-26-7 2,2,2-trichloro-1-(4-hydroxy-3-methoxy-phenyl)-ethanol 
• 7732-18-5 water 

Downstream Products

• 91012-60-1 1-(4-hydroxy-3-methoxy-phenyl)-2-methylamino-ethanone 
• 1638141-36-2 C₂₁H₁₈N₂O₄ 
• 66922-70-1 C₉H₁₀O₅ 
• 1630958-41-6 (E)-1-(7,8-dihydro-3-(4-hydroxy-3-methoxyphenyl)cinnoline-5(6H)-ylidene)hydrazine 
• 1404111-88-1 3-(4-hydroxy-3-methoxyphenyl)-7,7-dimethyl-7,8-dihydrocinnolin-5(6H)-one 

Relevant articles and documents

An efficient one-pot protocol for regioselective synthesis of 3-aryl-6,8-dialkyl-7-thioxo-7,8-dihydropyrimido[4,5-c ] pyridazine-5(6 H)-ones

A series of 3-aryl-6,8-dialkyl-7-thioxo-7,8-dihydropyrimido[4,5-c] pyridazine-5(6H)-one derivatives have been regioselectively synthesized via the one-pot three-component reaction of 1,3-dimethylthiobarbituric acid and 1,3-diethylthiobarbituric acid with various arylglyoxals in the presence of hydrazinium dihydrochloride in warm ethanol. These new substituted pyrimidopyridazines may be potential monoamine oxidase inhibitors.

Synthesis of Some 5-[2-Aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-trione Derivatives by a One-pot, Three-component Reaction

This study reports the reduction of á,a-unsaturated ketones 4a-g, formed by condensation of arylglyoxals 2a-g with 1,3-dimethylbarbituric acid (3) by L-cysteine (5) in the presence of phosphotungstic acid as a catalyst. This reaction leads to the formation of 5-[2-aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-triones 6a-g, with no sign of any heterocyclic product formation. The structure of compound 6f was confirmed by X-ray crystallography.

Regiospecific one-pot, combinatorial synthesis of new substituted pyrimido[4,5-c]pyridazines as potential monoamine oxidase inhibitors

New 3-aryl-6-methylpyrimido[4,5-c]pyridazine-5,7(6H ,8H)-diones and 3-aryl-6-ethyl-7-thioxo-7,8-dihydropyrimido[4,5- c]pyridazin-5(6H)-ones were efficiently synthesized via a regiospecific one-pot reaction of N -methylbarbituric acid and N -ethyl-2-thiobarbituric acid with various arylglyoxal monohydrates in the presence of hydrazine dihydrochloride in ethanol at 50°C. The target compounds were obtained in high yields and were regioisomerically pure after recrystallization. These new heterocycles may act as potential MAOB inhibitors.