320337-16-4 Usage
General Description
2-(Isopropylsulfonyl)ethanamine, also known as N-(1-methylethyl)sulfonyl-2-aminoethane, is an organic compound with the molecular formula C5H13NO2S. This chemical compound is an amine derivative with a sulfonyl group and is commonly used as a reagent in organic synthesis. It is a colorless liquid with a strong amine odor and is insoluble in water but soluble in organic solvents. 2-(Isopropylsulfonyl)ethanamine is used in the pharmaceutical industry as a precursor for the synthesis of various drugs and is also utilized in the production of insecticides and fungicides. Additionally, it may have applications in the field of medicinal chemistry and the development of new pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 320337-16-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,0,3,3 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 320337-16:
(8*3)+(7*2)+(6*0)+(5*3)+(4*3)+(3*7)+(2*1)+(1*6)=94
94 % 10 = 4
So 320337-16-4 is a valid CAS Registry Number.
320337-16-4Relevant articles and documents
Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series
Petrov, Kimberly G.,Zhang, Yue-Mei,Carter, Malcolm,Cockerill, G. Stuart,Dickerson, Scott,Gauthier, Cassandra A.,Guo, Yu,Mook Jr., Robert A.,Rusnak, David W.,Walker, Ann L.,Wood, Edgar R.,Lackey, Karen E.
, p. 4686 - 4691 (2007/10/03)
Synthetic modifications on a 6-furanylquinazoline scaffold to optimize the dual ErbB-1/ErbB-2 tyrosine kinase inhibition afforded consistent SAR whereby a 4-(3-fluorobenzyloxy)-3-haloanilino provided the best enzyme potency and cellular selectivity. Changes made to the 6-furanyl group had little impact on the enzyme activity, but appeared to dramatically affect the cellular efficacy. The discovery of lapatinib emerged from this work.