32081-57-5

Basic information

• Product Name: 2-Pyridineacetonitrile, a-methyl-
• Synonyms: 2-(pyridine-2-yl)propanenitrile;2-(2-pyridyl)-propionitrile;2-pyridin-2-yl-propionitrile;2-(2-Pyridyl)-propionitril;(+/-)-2-(2-Pyridyl)-propionnitril;2-(2-pyridinyl)-propanenitrile
• CAS NO: 32081-57-5
• Molecular Formula: C8H8N2
• Molecular Weight: 132.165
• Mol File: 32081-57-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-Pyridineacetonitrile, a-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridineacetonitrile, a-methyl-(32081-57-5)
• EPA Substance Registry System: 2-Pyridineacetonitrile, a-methyl-(32081-57-5)

Safety Data

• Hazardous Substances Data: 32081-57-5(Hazardous Substances Data)

Upstream product

• 100-69-6 2-vinylpyridine 
• 67-56-1 methanol 
• 2739-97-1 pyridine-2-acetonitrile 
• 74-88-4 methyl iodide 
• 1122-62-9 2-acetylpyridine 
• 143-33-9 sodium cyanide 
• 1071002-12-4 Phosphoric acid cyano-methyl-pyridin-2-yl-methyl ester diethyl ester 
• 109-04-6 2-bromo-pyridine 
• 107-12-0 propiononitrile 

Downstream Products

• 1122-62-9 2-acetylpyridine 

Relevant articles and documents

Nickel-Catalyzed Markovnikov Transfer Hydrocyanation in the Absence of Lewis Acid

Hydrocyanation in the absence of toxic HCN gas is highly desirable. Addressing that challenge, transition-metal-catalyzed transfer hydrocyanation using safe HCN precursors has been developed, but these reagents generally require a Lewis acid for activation, and the control of regioselectivity often remains problematic. In this Letter, a Ni-catalyzed highly Markovnikov-selective transfer hydrocyanation that operates in the absence of any Lewis acid is reported. The readily prepared pro-aromatic 1-isopropylcyclohexa-2,5-diene-1-carbonitrile is used as the HCN source, and the reaction shows a broad substrate scope and high functional group tolerance. Terminal styrene derivatives, dienes, and internal alkynes are converted with good to excellent selectivities. Mechanistic studies provide insights into the origin of the regioselectivity.

Lithium naphthalenide-induced reductive alkylation and addition of aryl-and heteroaryl-substituted dialkylacetonitriles

Lithium naphthalenide (LN)-induced reductive alkylation/addition reactions of aryl-, pyridyl-, and 2-thienyl-substituted dialkylacetonitriles have been investigated. Upon treatment with LN in THF at -40°C, both aryl and pyridyl precursors could undergo the reductive decyanation smoothly, and the in situ generated carbanions could be readily trapped by alkyl halides, ketones, aldehydes, or even oxygen to afford a wide range of functionalized aromatic derivatives bearing a newly established quaternary carbon. To effect the desired reductive alkylation of 2-thienyldialkylacetonitriles, a much lower temperature such as -100°C was required. Also with these substrates, an interesting ring-opening/S-alkylation process was observed when the reductive alkylation were performed at -78°C to give 1-alkylsulfanyl-1,3,4-trienes. A mechanistic discussion is given for this observation.

ANTIPARASITIC TERPENE ALKALOIDS

The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic formulation. More particularly, the present invention relates to derivatives of the terpene alkaloid (1S,2R,4aS,5R,8R,8aR)-2-(acetyloxy)-8a-hydroxy-3,8-dimethyl-5-(1-methylethenyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate. Pharmaceutical compositions comprising the same are also disclosed.