32092-18-5

Basic information

• Product Name: 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
• Synonyms: 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester;3-Carboethoxy-4H-pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidine-3-carboxylic acid, 4-oxo-, ethyl ester;4-ketopyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester;4-oxo-3-pyrido[1,2-a]pyrimidinecarboxylic acid ethyl ester;ethyl 4-oxopyrido[1,2-a]pyrimidine-3-carboxylate;4H-Pyrido[1,2-a]pyrimidine-4-oxo-3-carboxylic acid ethyl ester
• CAS NO: 32092-18-5
• Molecular Formula: C11H10N2O3
• Molecular Weight: 218.21
• Mol File: 32092-18-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 110-111 °C
• Boiling Point: 354.7°C at 760 mmHg
• Flash Point: 168.3°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 3.3E-05mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: 2-8°C
• PKA: 1.50±0.50(Predicted)
• CAS DataBase Reference: 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester(32092-18-5)
• EPA Substance Registry System: 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester(32092-18-5)

Safety Data

• Hazardous Substances Data: 32092-18-5(Hazardous Substances Data)

Usage

General Description

4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester is a chemical compound with a molecular formula of C10H8N2O3. It is an ethyl ester derivative of 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid and is often used in the field of pharmaceuticals and organic synthesis. 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester has a heterocyclic structure and is commonly used as a building block in the synthesis of various pharmaceutical drugs. It may also have potential applications in research and as an intermediate in the production of other organic compounds. Its precise uses and properties may vary depending on the specific application and context in which it is used.

InChI:InChI=1/C11H10N2O3/c1-2-16-11(15)8-7-12-9-5-3-4-6-13(9)10(8)14/h3-7H,2H2,1H3

Upstream product

• 39080-52-9 3-ethoxy-3-oxo-2-(pyridine-2-yl-aminomethylene)-propanoic acid ethyl ester 
• 504-29-0 2-aminopyridine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 34662-58-3 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid 
• 39080-62-1 4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 38326-36-2 ethyl 4-oxo-6,7,8,9-tetrahydro-4H-pyrido<1,2-a>pyrimidine-3-carboxylate 
• 1408240-61-8 C₁₇H₁₆N₄O₃ 
• 1408240-54-9 C₁₆H₁₃ClN₄O₂ 
• 1408240-80-1 C₂₀H₂₁N₅O₃ 
• 225112-08-3 3-<(Benzyloxycarbonyl)amino>-4H-pyrido<1,2-a>pyrimidin-4-one 
• 1011224-73-9 N'-benzoyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbohydrazide 
• 1326603-01-3 N'-(4-fluorobenzoyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbohydrazide 
• 1325391-50-1 N'-(4-chlorobenzoyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbohydrazide 
• 1402740-21-9 N'-(4-methoxybenzoyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbohydrazide 
• 1325574-22-8 N'-(4-methylbenzoyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbohydrazide 
• 1402740-22-0 3-(5-phenyl-1,3,4-oxadiazol-2-yl)-4H-pyrido[1,2-a]pyrimidin-4-one 
• 1402740-23-1 3-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-4H-pyrido[1,2-a]pyrimidin-4-one 

Relevant articles and documents

Amide compounds and uses thereof

Provided herein are novel amide compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same, and uses thereof, wherein the definition of each symbol is as described in the description.

MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)

The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.

Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors

Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial chemotherapy and inhibition of this protease affects the growth of parasite adversely. A series of pyrido[1,2-a]pyrimidin-4-ones were synthesized and evaluat