321-07-3Relevant articles and documents
Covalent inhibitors of LgtC: A blueprint for the discovery of non-substrate-like inhibitors for bacterial glycosyltransferases
Xu, Yong,Smith, Ruth,Vivoli, Mirella,Ema, Masaki,Goos, Niina,Gehrke, Sebastian,Harmer, Nicholas J.,Wagner, Gerd K.
, p. 3182 - 3194 (2017)
Non-substrate-like inhibitors of glycosyltransferases are sought after as chemical tools and potential lead compounds for medicinal chemistry, chemical biology and drug discovery. Here, we describe the discovery of a novel small molecular inhibitor chemot
Trifluoromethyl pyrazolo seven-membered ring compound and crystal structure and preparation method thereof
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Paragraph 0012; 0040-0041, (2021/10/27)
The invention provides a trifluoromethyl pyrazolo seven-membered ring compound and a crystal structure and a preparation method thereof, and belongs to the technical field of organic and pharmaceutical synthesis. The invention provides a novel trifluoromethyl pyrazolo seven-membered ring compound, a crystal thereof and a preparation method thereof. The compound and the crystal have good stability and are suitable for being used as raw materials for medicine preparation; and meanwhile, data support is provided for exploring the relationship between the microstructure and the medicine effect of the compound, and a certain basis is provided for synthesis of small molecular compounds.
Promoting the Furan Ring-Opening Reaction to Access New Donor–Acceptor Stenhouse Adducts with Hexafluoroisopropanol
Clerc, Michèle,Stricker, Friedrich,Ulrich, Sebastian,Sroda, Miranda,Bruns, Nico,Boesel, Luciano F.,Read de Alaniz, Javier
supporting information, p. 10219 - 10227 (2021/03/22)
Donor–acceptor Stenhouse adducts (DASAs) are visible-light-responsive photoswitches with a variety of emerging applications in photoresponsive materials. Their two-step modular synthesis, centered on the nucleophilic ring opening of an activated furan, ma
Synthesis and cytotoxicity evaluation of novel tricyclic dihydropyrazolo [4,3-f][1,2,3]triazolo diazepines
Bingi, Chiranjeevi,Kale, Ashok,Poornachandra, Yedla,Kumar, Chityal Ganesh,Atmakur, Krishnaiah
, p. 1020 - 1025 (2018/10/31)
Background: A number of novel fluorinated 4,5-dihydropyrazolo [4,3-f][1,2,3] triazolo diazepines (9-11) have been accomplished starting from 1-phenyl-3-trifluoromethyl pyrazole-5-one (3) in a multistep synthesis. Thus obtained compound 9 was converted int