321-51-7

Basic information

• Product Name: 2-(2-fluorophenyl)-1H-benzimidazole
• Synonyms: 2-(2-fluorophenyl)-1H-benzimidazole;2-(2-FLUOROPHENYL)-1H-1,3-BENZODIAZOLE;2-(2-FLUOROPHENYL)BENZIMIDAZOLE;2-(2-Fluoro-phenyl)-1H-benzoimidazole
• CAS NO: 321-51-7
• Molecular Formula: C₁₃H₉FN₂
• Molecular Weight: 212.226
• Mol File: 321-51-7.mol
• Article Data: 28

Chemical Properties

• Melting Point: 207 °C
• Boiling Point: 397.0±44.0 °C(Predicted)
• Appearance: /
• Density: 1.289±0.06 g/cm3(Predicted)
• PKA: 11.05±0.10(Predicted)
• CAS DataBase Reference: 2-(2-fluorophenyl)-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluorophenyl)-1H-benzimidazole(321-51-7)
• EPA Substance Registry System: 2-(2-fluorophenyl)-1H-benzimidazole(321-51-7)

Safety Data

• Hazardous Substances Data: 321-51-7(Hazardous Substances Data)

Usage

General Description

2-(2-fluorophenyl)-1H-benzimidazole is a chemical compound with the molecular formula C13H9FN2. It is a benzimidazole derivative with a fluorophenyl group attached to the second position of the benzimidazole ring. 2-(2-fluorophenyl)-1H-benzimidazole has been studied for its potential pharmaceutical applications, including its anticancer and antifungal properties. Benzimidazole derivatives are known for their diverse biological activities and have been investigated as potential drugs for various therapeutic purposes. The presence of the fluorophenyl group in 2-(2-fluorophenyl)-1H-benzimidazole may contribute to its specific pharmacological properties and potential uses in medical research and drug development.

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 445-29-4 o-fluoro-benzoic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 88-74-4 2-nitro-aniline 
• 446-48-0 o-fluorobenzyl bromide 
• 7191-81-3 C₁₃H₁₁FN₂ 
• 615-43-0 2-iodophenylamine 
• 615-36-1 2-bromoaniline 
• 446-51-5 2-fluorobenzyl alcohol 
• 1072-85-1 o-fluorobromobenzene 
• 51-17-2 benzoimidazole 

Downstream Products

• 28381-92-2 6-phenylbenzimidazolo<1,2-c>quinazoline 
• 1037289-22-7 5,6-diphenylbenzo[4,5]imidazo[2,1-a]isoquinoline 

Relevant articles and documents

Visible-Light-Driven Sulfonylation/Cyclization to Access Sulfonylated Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones

Visible-light-driven sulfonylation/cyclization of N-methacryloyl-2-phenylbenzoimidazoles has been successfully developed. Using commercially available sulfonyl chloride as sulfonylation reagent, a wide range of sulfonylated benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones with potential antitumor activity were provided in acceptable to excellent yields. This method has the advantages of mild reaction conditions and outstanding functional group tolerance, and provides a new strategy for the development of potential antitumor lead compounds.

Method for catalytically synthesizing phenylbenzimidazole compound by using copper complex

The invention relates to a method for catalytically synthesizing a phenylbenzimidazole compound by using a copper complex, which comprises the following steps: in the presence of alkali, taking benzimidazole and halogenated hydrocarbon as raw materials, taking the copper complex containing meta-carborane ligand as a catalyst, and conducting reacting at room temperature to prepare the phenylbenzimidazole compound. Compared with the prior art, the method has the advantages that the halogenated hydrocarbon compound which is low in cost and easy to obtain is used as the substrate, the reaction of benzimidazole and halogenated hydrocarbon is efficiently catalyzed by using the copper complex, the phenylbenzimidazole compound is synthesized by a one-pot method, the reaction condition is mild, the universality is good, the catalytic efficiency is high, few byproducts are produced, the cost is relatively low, the product is easy to separate, and lots of waste residues cannot be generated.

Bandgap engineering in benzotrithiophene-based conjugated microporous polymers: a strategy for screening metal-free heterogeneous photocatalysts

Metal-free conjugated microporous polymers (CMPs) as visible-light active and recyclable photocatalysts offer a green and sustainable alternative to classical metal-based photosensitizers. However, the strategy for screening CMP-based heterogeneous photocatalysts has not been interpreted up to now. Herein, we present a general strategy for obtaining excellent solid photocatalysts, which is to implement bandgap engineering in the same series of materials. As a proof of concept, three conjugated porous materials containing benzo[1,2-b:3,4-b′:5,6-b′′]trithiophene building blocks (BTT-CMP1, BTT-CMP2 and BTT-CMP3) were successfully constructed. They possess permanent porosity with a large specific surface area and excellent stability. By changing the linker between benzotrithiophene units, the bandgaps, energy levels and photoelectric performances including the absorption, transient photocurrent responses and photocatalytic performances of BTT-CMPs could be handily modulated. Indeed, BTT-CMP2 displayed the best catalytic activity for visible-light-induced synthesis of benzimidazoles among the three CMP materials, even higher than that of small molecule photocatalysts. As a metal-free photocatalyst, interestingly, the screened BTT-CMP2 also showed extensive substrate applicability and outstanding recyclability. Additionally, we have the opinion that this strategy will prove to be a guiding principle for screening superior CMP-based photocatalysts and broaden their application fields.

Nickel-Catalyzed C-F/N-H Annulation of 2-(2-Fluoroaryl) N-Heteroaromatic Compounds with Alkynes: Activation of C-F Bonds

The reaction of 2-(2-fluoroaryl) N-heteroaromatic compounds, such as benzimidazole and indole derivatives, with internal alkynes in the presence of a catalytic amount of a nickel complex results in C-F/N-H annulation with alkynes. The reaction shows a high functional group compatibility. The presence of a strong base, such as KOBu- tor LiOBu t, is required for the reaction to proceed.