321-75-5

Basic information

• Product Name: Ethanone, 2-bromo-2-fluoro-1-phenyl- (9CI)
• Synonyms: Ethanone, 2-bromo-2-fluoro-1-phenyl- (9CI)
• CAS NO: 321-75-5
• Molecular Formula: C₈H₆BrFO
• Molecular Weight: 217.0350432
• Product Categories: ACETYLHALIDE
• Mol File: 321-75-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 54-54.5 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 232.3±20.0 °C(Predicted)
• Appearance: /
• Density: 1.550±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 2-bromo-2-fluoro-1-phenyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-bromo-2-fluoro-1-phenyl- (9CI)(321-75-5)
• EPA Substance Registry System: Ethanone, 2-bromo-2-fluoro-1-phenyl- (9CI)(321-75-5)

Safety Data

• Hazardous Substances Data: 321-75-5(Hazardous Substances Data)

Upstream product

• 450-95-3 2-fluoroacetophenone 
• 3282-32-4 2-diazo-acetophenone 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 98-88-4 benzoyl chloride 
• 401-55-8 ethyl bromofluoroacetate 
• 100-58-3 phenylmagnesium bromide 
• 41463-86-9 4,4,4-trifluoro-3-hydroxy-1-phenylbut-2-en-1-one 
• 98-86-2 acetophenone 
• 1241899-76-2 1-phenyl-2-(pyrimidin-2-ylsulfonyl)ethanone 
• 199387-64-9 1-phenyl-2-(pyrimidin-2-ylthio)ethanone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1149578-22-2 2-(benzo[d]thiazol-2-ylsulfonyl)-2-fluoro-1-phenylethanone 
• 1296831-95-2 (E)-benzyl 3-fluoro-4-phenylbut-3-en-2-ylcarbamate 
• 1296831-97-4 (Z)-benzyl 3-fluoro-4-phenylbut-3-en-2-ylcarbamate 
• 1296831-56-5 (S,E)-4-fluoro-3-methyl-1,5-diphenylpent-4-en-1-one 
• 1296831-71-4 (S,Z)-4-fluoro-3-methyl-1,5-diphenylpent-4-en-1-one 
• 1296831-77-0 (1R,4R)-5-fluoro-6-phenylbicyclo[2.2.2]oct-5-en-2-one 
• 1296831-90-7 (E)-benzyl 2-fluoro-3-phenyl-1-p-tolylallylcarbamate 
• 1296831-96-3 (Z)-benzyl 2-fluoro-3-phenyl-1-p-tolylallylcarbamate 
• 1296831-92-9 (E)-tert-butyl 2-fluoro-5-methyl-1-phenylhex-1-en-3-ylcarbamate 

Relevant articles and documents

High Chemo-/Stereoselectivity for Synthesis of Polysubstituted Monofluorinated Pyrimidyl Enol Ether Derivatives

A novel intramolecular Smiles rearrangement of α-fluoro-β-keto-pyrimidylsulfones (usually used as a carbon nucleophile) was developed, providing a versatile avenue for synthesis of tri/tetra-substituted monofluorinated pyrimidyl enol ethers. Among these, diverse (Z)-monofluorovinylsulfones and sulfinates were efficiently assembled by adding extra electrophile and fine-tuning reaction conditions. The process is triggered by a keto-enol tautomerism from enol oxyanion to pyrimidine 2-carbon, completely different from the classical carbon nucleophilic addition reaction approach.

Nickel-Catalyzed Coupling Reaction of α-Bromo-α-fluoroketones with Arylboronic Acids toward the Synthesis of α-Fluoroketones

A nickel-catalyzed coupling reaction of α-bromo-α-fluoroketones with arylboronic acids was reported, which provides an efficient pathway to access 2-fluoro-1,2-diarylethanones in high yields. We also disclosed the synthesis of the monofluorination agents

A synthesis method of [...] acetone derivatives

The invention provides a method for synthesizing [...] acetone derivatives, characterized in that includes: formula (IV) is shown in the compounds are dissolved in 1, 4 - dioxane (dioxane) in, adding catalyst trifluoromethanesulfonic acid nickel (II) (Ni