321195-88-4

Basic information

• Product Name: 3-(TRIFLUOROMETHOXY)BENZHYDRAZIDE
• Synonyms: 3-(TRIFLUOROMETHOXY)BENZHYDRAZIDE;3-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE;3-(trifluoroMethoxy)benzohydrazide
• CAS NO: 321195-88-4
• Molecular Formula: C₈H₇F₃N₂O₂
• Molecular Weight: 220.15
• Mol File: 321195-88-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 94-96°C
• Appearance: /
• Density: 1.399g/cm³
• Refractive Index: 1.495
• Storage Temp.: Store Cold
• PKA: 11.74±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-(TRIFLUOROMETHOXY)BENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(TRIFLUOROMETHOXY)BENZHYDRAZIDE(321195-88-4)
• EPA Substance Registry System: 3-(TRIFLUOROMETHOXY)BENZHYDRAZIDE(321195-88-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 321195-88-4(Hazardous Substances Data)

Usage

General Description

3-(Trifluoromethoxy)benzhydrazide is a chemical compound with the molecular formula C8H7F3N2O2. Owing to its functional group of benzhydrazide, it falls under the category of organic compounds known as benzenoids - aromatic compounds containing one or more benzene rings. Its trifluoromethoxy group suggests it has fluorine atoms, which contribute to its reactivity and stability. The exact properties of 3-(Trifluoromethoxy)benzhydrazide, such as boiling point, density, and solubility, would depend on its specific structural conformation. Its detailed chemical behavior and uses are subject to further study and it is primarily used in research and chemical synthesis processes.

InChI:InChI=1/C8H7F3N2O2/c9-8(10,11)15-6-3-1-2-5(4-6)7(14)13-12/h1-4H,12H2,(H,13,14)

Upstream product

• 1014-81-9 3-(trifluoromethoxy)benzoic acid 
• 677713-01-8 ethyl 3-(trifluoromethoxy)benzoate 
• 148438-00-0 3-trifluoromethoxybenzoic acid methyl ester 

Downstream Products

• 1018838-63-5 3-(3-nitro-phenyl)-5-(3-trifluoromethoxy-phenyl)-4H-[1,2,4]-triazole 
• 1235563-15-1 3-trifluoromethoxybenzoic acid [1-(3,5-dichloro-2-hydroxyphenyl)methylidene]hydrazide 
• 1313733-16-2 5-piperidin-1-yl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6,9-dioxa-1,2,3a,4-tetraazacyclopenta[a]naphthalene 
• 1313733-17-3 cyclopropylmethyl-[3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6,9-dioxa-1,2,3a,4-tetraaza-cyclopenta[a]naphthalen-5-yl]-amine 
• 1313733-32-2 5-chloro-9-methyl-3-(3-trifluoromethoxy-phenyl)-8,9-dihydro-7H-6-oxa-1,2,3a,4,9-pentaaza-cyclopenta[a]naphthalene 
• 1313733-33-3 5-chloro-6-methyl-3-(3-trifluoromethoxy-phenyl)-7,8-dihydro-6H-9-oxa-1,2,3a,4,6-pentaaza-cyclopenta[a]naphthalene 
• 1417848-73-7 C₁₅H₁₀ClF₃N₄O₂ 
• 1417848-82-8 C₁₅H₁₀ClF₃N₄O₂ 
• 1417848-92-0 C₁₅H₁₀ClF₃N₄O₂ 
• 1417840-38-0 C₂₂H₂₅F₃N₆O₂*CH₂O₂ 
• 1417847-24-5 C₁₆H₁₁ClF₅N₅O₂ 
• 1417847-35-8 C₁₆H₁₁ClF₅N₅O₂ 
• 1417848-68-0 C₁₅H₁₀ClF₃N₄O₂ 
• 1417848-71-5 C₁₅H₁₂ClF₃N₄O₃ 

Relevant articles and documents

SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clinically relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clinical drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.

TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS

There is provided compounds of formula (I), wherein R1, R2, X, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).