32136-81-5 Usage
Description
1-(4-hydroxyphenyl)-2-methoxyethan-1-one, also known as 2-Methoxy-4''-hydroxyacetophenone (CAS# 32136-81-5), is an organic compound with a tan solid appearance. It is characterized by its unique chemical structure, which includes a phenyl group with a hydroxyl group at the para position, an ethanone group, and a methoxy group at the ortho position relative to the carbonyl group. 1-(4-hydroxyphenyl)-2-methoxyethan-1-one is known for its utility in various organic synthesis processes.
Uses
Used in Organic Synthesis:
1-(4-hydroxyphenyl)-2-methoxyethan-1-one is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows for further functionalization and modification, making it a valuable building block in the creation of more complex molecules for a wide range of applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(4-hydroxyphenyl)-2-methoxyethan-1-one is used as a key component in the development of new drugs. Its chemical properties and reactivity make it suitable for the synthesis of various drug candidates, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
1-(4-hydroxyphenyl)-2-methoxyethan-1-one is also utilized in academic and industrial research settings to study the properties and behavior of various chemical reactions. Its unique structure provides researchers with valuable insights into the mechanisms of organic synthesis and the development of new synthetic methods.
Used in Material Science:
In the field of material science, 1-(4-hydroxyphenyl)-2-methoxyethan-1-one may be employed in the development of novel materials with specific properties. Its chemical structure can be tailored to create materials with enhanced performance characteristics, such as improved stability, reactivity, or selectivity.
Preparation
Obtained by scission of 5-hydroxy-4-(4-hydroxyphenyl) 5H-furan-2-one with potassium hydroxide in methanol at 20° for 24 h (85%). – Also obtained by catalytic debenzylation of 1-(4-benzyloxyphenyl)-2-methoxyethanone in methanol under hydrogen (five bars) in the presence of 5% Pd/C for 24 h (81%).
Check Digit Verification of cas no
The CAS Registry Mumber 32136-81-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,1,3 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 32136-81:
(7*3)+(6*2)+(5*1)+(4*3)+(3*6)+(2*8)+(1*1)=85
85 % 10 = 5
So 32136-81-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H10O3/c1-12-6-9(11)7-2-4-8(10)5-3-7/h2-5,10H,6H2,1H3
32136-81-5Relevant articles and documents
Flavylium based dual photochromism: Addressing cis - trans isomerization and ring opening-closure by different light inputs
Gago, Sandra,Basílio, Nuno,Moro, Artur J.,Pina, Fernando
, p. 7349 - 7351 (2015)
The multistate system of 4′,7-dihydroxy-3-methoxyflavylium is constituted by a multiequilibrium involving trans-chalcone, cis-chalcone, hemiketal, flavylium cation and quinoidal base. This system possesses two independently addressable inter-connected photochromic systems based on the cis - trans isomerization and ring opening-closure of the hemiketal.
Synthesis method for preparing metoprolol intermediate
-
, (2017/12/27)
A synthesis method for preparing a metoprolol intermediate comprises the following steps: 1, dissolving phenol and chloroacetyl chloride in a dichloroethane solvent, adding aluminum trichloride as a catalyst, stirring for reaction to generate 4-chloracetyl phenol; 2, dissolving the 4-chloracetyl phenol generated by the reaction of the step 1 in methanol, adding methanol sodium, starting a stirrer for stirring for reaction to generate 4-(2'-methoxy acetyl) phenol; 3, adding the 4-(2'-methoxy acetyl) phenol generated by the reaction of the step 2 into a reactor, adding a catalyst, adding a reductant, starting stirring, and heating for reaction to generate intermediate 4-(2 '-methoxy ethyl) phenol. The advantages are as follows: the method for preparation of the 4-(2 '-methoxy ethyl) phenol is simple in operation, mild in conditions, environmental friendly, low in cost, and is suitable for industrial production, Raney nickel can be reused, the reaction yield reaches 86%, and the purity reaches 98% or above.
Synthesis and cardiovascular activity of metoprolol analogues
Melgar-Fernandez, Roberto,Demare, Patricia,Hong, Enrique,Rosas, Miguel Angel,Escalante, Jaime,Munoz-Muniz, Omar,Juaristi, Eusebio,Regla, Ignacio
, p. 191 - 194 (2007/10/03)
The synthesis of four novel analogues of metoprolol, a well-known β1-blocker used to reduce arterial blood pressure, is described. The preparation of (2S,2′S)-7, (2R,2′S)-7, (2R,2′R)-8, and (2S,2′R)-8 was based on the reaction of racemic 2-[4-(2′- methoxyethyl)-phenoxymethyl]-oxirane (4) with (R)- or (S)-2-amino-1-butanol. Salient characteristics of analogues 7 and 8 relative to metoprolol are the incorporation of an additional stereogenic center, as well as a methyl group and a hydroxyl function on the nitrogen-containing chain. These novel derivatives present significant hypotensive and bradycardiac activity, although no blocking action toward β1 and β2 adrenergic receptor.