321371-23-7Relevant articles and documents
Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer
Kitajima, Hiroshi,Nakamura, Mitsuharu,Tamakawa, Hiroki,Goto, Nobuharu
, p. 2453 - 2456 (2000)
Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidinedione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in potency of insulin-releasing activity and to pioglitazone in insulin-sensitizing activity. (C) 2000 Elsevier Science Ltd.