321533-77-1 Usage
Pyrazole derivative
1H-pyrazole
A five-membered heterocyclic ring structure with one nitrogen atom and one sulfur atom as ring members, contributing to the compound's core structure.
Methyl group attachment
1-methyl
A single carbon atom bonded to three hydrogen atoms, attached to the pyrazole ring, contributing to the compound's structure and properties.
Phenylsulfanyl group
5-(phenylsulfanyl)
A phenyl ring (a six-membered carbon ring with alternating single and double bonds) bonded to a sulfur atom, attached to the pyrazole ring, contributing to the compound's structure and properties.
Trifluoromethyl group
3-(trifluoromethyl)
A carbon atom bonded to three fluorine atoms, attached to the pyrazole ring, contributing to the compound's structure, properties, and stability.
Carbaldehyde functional group
-4-carbaldehyde
An aldehyde group (a carbonyl group bonded to a hydrogen atom and an alkyl or aryl group) attached to the pyrazole ring, contributing to the compound's reactivity and potential for further chemical reactions.
Application in organic synthesis and medicinal chemistry
Building block for pharmaceuticals and bioactive compounds
The compound serves as an important intermediate in the synthesis of various pharmaceuticals and bioactive compounds due to its unique structural features and reactivity.
Unique structural features
Valuable intermediate for diverse chemical compounds with potential pharmacological activities
The presence of various functional groups and the pyrazole ring in the compound's structure make it a valuable building block for creating a wide range of chemical compounds with potential therapeutic and pharmacological applications.
Check Digit Verification of cas no
The CAS Registry Mumber 321533-77-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,1,5,3 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 321533-77:
(8*3)+(7*2)+(6*1)+(5*5)+(4*3)+(3*3)+(2*7)+(1*7)=111
111 % 10 = 1
So 321533-77-1 is a valid CAS Registry Number.
321533-77-1Relevant articles and documents
5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5
Gilbert, Adam M.,Bursavich, Matthew G.,Lombardi, Sabrina,Georgiadis, Katy E.,Reifenberg, Erica,Flannery, Carl R.,Morris, Elisabeth A.
, p. 1189 - 1192 (2007/10/03)
A series of 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5 (aggrecanase-2) is described. These compounds show μM functional inhibition of ADAMTS-5, and represent a new class of agents with the potential of inhibiting degradation of aggrecan, a major component of cartilage which is lost in osteoporosis. Compound 12 is noteworthy in that it has an ADAMTS-5 IC50: 1.1 μM and shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).
