321681-28-1

Basic information

• Product Name: 2-bromo-1-(2-bromo-4,5-dimethoxyphenyl)-ethanone
• Synonyms: 2-bromo-1-(2-bromo-4,5-dimethoxyphenyl)-ethanone
• CAS NO: 321681-28-1
• Molecular Weight: 337.996
• Mol File: 321681-28-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-bromo-1-(2-bromo-4,5-dimethoxyphenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1-(2-bromo-4,5-dimethoxyphenyl)-ethanone(321681-28-1)
• EPA Substance Registry System: 2-bromo-1-(2-bromo-4,5-dimethoxyphenyl)-ethanone(321681-28-1)

Safety Data

• Hazardous Substances Data: 321681-28-1(Hazardous Substances Data)

Upstream product

• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5293-52-7 6-bromo-3,4-dimethoxy-α-methylbenzyl alcohol 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 74746-10-4 1-(2-bromo-4,5-dimethoxyphenyl)ethanone 

Downstream Products

• 1215858-80-2 2-bromo-1-(2-bromo-4,5-dimethoxyphenyl)ethanone oxime 
• 1233979-79-7 5,6-dimethoxy-3-methyl-1-(p-tolylsulfonyl)indazole 
• 181423-71-2 14-(3,4-dimethoxyphenyl)-2,3,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 1616606-35-9 C₁₄H₁₉BrN₂O₃ 
• 1609071-67-1 C₁₄H₁₈N₂O₃ 
• 1268015-41-3 1-[2-(2-bromo-4,5-dimethoxyphenyl)-2-oxoethyl]-4-trifluoromethylpyridinium bromide 
• 1268015-85-5 7-hydroxy-9,10-dimethoxy-2-phenylpyrido[2,1-a]isoquinolinylium bromide 
• 1268015-40-2 1-[2-(2-bromo-4,5-dimethoxyphenyl)-2-oxoethyl]-4-phenylpyridinium bromide 
• 1268015-48-0 1-[2-(2-bromo-4,5-dimethoxyphenyl)-2-oxoethyl]-2,3,5-trimethylpyridinium bromide 
• 1268015-43-5 1-[2-(2-bromo-4,5-dimethoxyphenyl)-2-oxoethyl]-4-methoxypyridinium bromide 
• 1268015-50-4 1-[2-(2-bromo-4,5-dimethoxyphenyl)-2-oxoethyl]-quinolinium bromide 
• 1268015-45-7 1-[2-(2-bromo-4,5-dimethoxyphenyl)-2-oxoethyl]-3,5-dimethylpyridinium bromide 
• 1268015-39-9 1-[2-(2-bromo-4,5-dimethoxyphenyl)-2-oxoethyl]-pyridinium bromide 
• 1219632-65-1 1-(2-bromo-4,5-dimethoxyphenyl)-2-fluoroethanone 

Relevant articles and documents

2 - Substituted cephem compound-containing pharmaceutical composition

PROBLEM TO BE SOLVED: To provide a cephem compound which has a strong antimicrobial activity, in particular effective against various β-lactamase producing Gram negative bacteria, and a composition comprising the compound.SOLUTION: The present invention provides a pharmaceutical composition comprising a compound represented by formula (I), an ester at a carboxyl group, an amino-protected compound when the amino is present on a ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.

2 SUBSTITUTED CEPHEM COMPOUNDS

The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

A high-yielding modular access to the lamellarins: Synthesis of lamellarin G trimethyl ether, lamellarin η and dihydrolamellarin η

A deprotonated α-aminonitrile serves as a key intermediate in a highly efficient (95 % per step on average; see scheme) modular synthetic approach to the lamellarin alkaloids. Its reaction with an α,β- unsaturated aldehyde forms the central pyrrole ring in a one-pot procedure. The construction of the fused pentacyclic skeleton is completed by a microwave-assisted Ullmann-type lactone formation.